The MDR1 Downstream Promoter Contains Sequence-Specific Binding Sites for Wild-Type p53

We have examined the interaction of the wild-type p53 protein with the downstream promoter of the human multidrug resistance gene-1 (MDR1). Our findings indicate that wild type p53 inhibits reporter activity driven by the MDR1 downstream promoter (base pairs −189 to +133 relative to the major transc...

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Veröffentlicht in:	Biochemical and biophysical research communications 1995-12, Vol.217 (3), p.825-831
Hauptverfasser:	Strauss, B.E., Shivakumar, C., Deb, S.P., Deb, S., Haas, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Base Sequence Binding Sites DNA Primers - chemistry DNA-Binding Proteins - metabolism Drug Resistance, Multiple Gene Expression Regulation Humans Molecular Sequence Data Promoter Regions, Genetic RNA, Messenger - genetics Tumor Suppressor Protein p53 - metabolism
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