Specific Aspartic Acid-Rich Sequences Are Responsible for Silver Staining of Nucleolar Proteins

Ag-NOR proteins are silver-stainable proteins in the nucleolar organizer regions and are used to distinguish benign from malignant tumors. B23 and C23 are the two major Ag-NOR proteins. This study shows that only one of the two acidic clusters of B23 is responsible for its silver staining property....

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Veröffentlicht in:	Biochemical and biophysical research communications 1995-02, Vol.207 (2), p.485-491
Hauptverfasser:	Valdez, B.C., Henning, D., Le, T.V., Busch, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Aspartic Acid Cell Nucleolus - ultrastructure Cloning, Molecular Diagnosis, Differential Escherichia coli Glutathione Transferase - analysis Glutathione Transferase - biosynthesis HeLa Cells Humans Molecular Sequence Data Mutagenesis, Site-Directed Neoplasms - pathology Neoplasms - ultrastructure Nuclear Proteins - analysis Nuclear Proteins - biosynthesis Nuclear Proteins - chemistry Nucleolus Organizer Region - ultrastructure Recombinant Fusion Proteins - analysis Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - chemistry Sequence Deletion Silver Staining and Labeling
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