Cyclic AMP Is an Essential Factor in Immune Responses

In the present studies, cAMP, a secondary messenger historically viewed as a negative mediator of immune responses, was demonstrated to possess immunoenhancing activity at low concentrations. In parallel experiments the adenylate cyclase inhibitor, 2′,3′-dideoxyadenosine, produced a marked inhibitio...

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Veröffentlicht in:	Biochemical and biophysical research communications 1995-01, Vol.206 (2), p.703-709
Hauptverfasser:	Koh, W.S., Yang, K.H., Kaminski, N.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation - drug effects B-Lymphocytes - drug effects B-Lymphocytes - immunology Bucladesine - pharmacology Cells, Cultured Cyclic AMP - physiology Dideoxyadenosine - pharmacology Dose-Response Relationship, Drug Female Ionomycin - pharmacology Lymphocyte Activation - drug effects Mice Mice, Inbred Strains Second Messenger Systems Spleen - immunology Tetradecanoylphorbol Acetate - pharmacology
Online-Zugang:	Volltext
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