Synergistic Differentiation of U937 Cells by All-Trans Retinoic Acid and 1α,25-Dihydroxyvitamin D3 Is Associated with the Expression of Retinoid X Receptor α
Among the nuclear hormone receptors, the retinoid X receptors (RXRs) play a central role through their ability to heterodimerize with other members of this family of transcription factors, including retinoic acid (RA) and vitamin D (VD3) receptors. We have previously found that all-trans retinoic ac...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1994-08, Vol.203 (1), p.272-280 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Defacque, H. Commes, T. Sevilla, C. Rochetteegly, C. Marti, J. |
| description | Among the nuclear hormone receptors, the retinoid X receptors (RXRs) play a central role through their ability to heterodimerize with other members of this family of transcription factors, including retinoic acid (RA) and vitamin D (VD3) receptors. We have previously found that all-trans retinoic acid and 1α, 25-dihydroxyvitamin D3 cooperate to induce monocytic differentiation of U937 human leukemic cells. Here the expression of RXRα protein in myelomonocytic cells was studied by immunodetection using polyclonal antibodies. RXRα was detected upon exposure of cells to VD3 and higher levels were found in cells treated by combinations of RA and VD3 under conditions where both agents synergized for inducing monocytic properties. |
| doi_str_mv | 10.1006/bbrc.1994.2178 |
| format | Article |
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RXRα was detected upon exposure of cells to VD3 and higher levels were found in cells treated by combinations of RA and VD3 under conditions where both agents synergized for inducing monocytic properties.</description><subject>Animals</subject><subject>Blotting, Western</subject><subject>Calcitriol - pharmacology</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Differentiation - physiology</subject><subject>Cell Division - drug effects</subject><subject>Cell Line</subject><subject>Cell Nucleus - metabolism</subject><subject>Cercopithecus aethiops</subject><subject>DNA, Neoplasm - biosynthesis</subject><subject>Drug Synergism</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Leukemia, Promyelocytic, Acute</subject><subject>Lymphoma, Large B-Cell, Diffuse</subject><subject>Receptors, Cytoplasmic and Nuclear - biosynthesis</subject><subject>Receptors, Retinoic Acid</subject><subject>Retinoid X Receptors</subject><subject>Thymidine - metabolism</subject><subject>Time Factors</subject><subject>Transcription Factors</subject><subject>Transfection</subject><subject>Tretinoin - pharmacology</subject><subject>Tritium</subject><subject>Tumor Cells, Cultured</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtOwzAQhi0EKuWxZYc0ByDBzsOJl1VbHhISEg-JXRTbE2qUJpVtCjkNZ-AinAlXrdixmpHm__-Z-Qg5YzRmlPJLKa2KmRBZnLCi3CNjRgWNEkazfTKmQRElgr0ckiPn3ihlLONiREYlLTLO-Zh8PQ4d2lfjvFEwM02DFjtvam_6DvoGnkVawBTb1oEcYNK20ZOtOwcP6E3XB89EGQ11p4H9fF8keTQzi0Hb_nNYG18vTQezFG4dTJzrVYhFDR_GL8AvEOafK4vO7TbtEjW8hFbhyvcWfr5PyEFTtw5Pd_WYPF_Nn6Y30d399e10chepNBU-UlmpdKIlo4XSGN7EXCS6KEtZIFd5SRuK2BR5kUktVMkVbyTmMmcikOCpSI9JvM1VtnfOYlOtrFnWdqgYrTagqw3oagO62oAOhvOtYfUul6j_5DuyYV5u5xiuXhu0lVMGO4XaWFS-0r35L_oX6ESPdA</recordid><startdate>19940830</startdate><enddate>19940830</enddate><creator>Defacque, H.</creator><creator>Commes, T.</creator><creator>Sevilla, C.</creator><creator>Rochetteegly, C.</creator><creator>Marti, J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19940830</creationdate><title>Synergistic Differentiation of U937 Cells by All-Trans Retinoic Acid and 1α,25-Dihydroxyvitamin D3 Is Associated with the Expression of Retinoid X Receptor α</title><author>Defacque, H. ; 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| ispartof | Biochemical and biophysical research communications, 1994-08, Vol.203 (1), p.272-280 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Blotting, Western Calcitriol - pharmacology Cell Differentiation - drug effects Cell Differentiation - physiology Cell Division - drug effects Cell Line Cell Nucleus - metabolism Cercopithecus aethiops DNA, Neoplasm - biosynthesis Drug Synergism Humans Kinetics Leukemia, Promyelocytic, Acute Lymphoma, Large B-Cell, Diffuse Receptors, Cytoplasmic and Nuclear - biosynthesis Receptors, Retinoic Acid Retinoid X Receptors Thymidine - metabolism Time Factors Transcription Factors Transfection Tretinoin - pharmacology Tritium Tumor Cells, Cultured |
| title | Synergistic Differentiation of U937 Cells by All-Trans Retinoic Acid and 1α,25-Dihydroxyvitamin D3 Is Associated with the Expression of Retinoid X Receptor α |
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