Modification of Energy Metabolism and Radiation Response of a Murine Tumor by Changes in Nitric Oxide Availability
The nitric oxide donor, SIN-1 and nitric oxide synthase inhibitor, nitro-L-arginine were examined for their effects on energy metabolism using 31P magnetic resonance spectroscopy, and on radiation sensitivity in the transplantable murine tumour, SCCVII/Ha. SIN-1 at 2 mg/kg i.v. reduced Pi/total by 4...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1993-04, Vol.192 (2), p.505-510 |
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| container_end_page | 510 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Wood, P.J. Stratford, I.J. Adams, G.E. Szabo, C. Thiemermann, C. Vane, J.R. |
| description | The nitric oxide donor, SIN-1 and nitric oxide synthase inhibitor, nitro-L-arginine were examined for their effects on energy metabolism using
31P magnetic resonance spectroscopy, and on radiation sensitivity in the transplantable murine tumour, SCCVII/Ha. SIN-1 at 2 mg/kg i.v. reduced Pi/total by 40-50% within 10 min and increased X-ray sensitivity 3 fold, consistent with increased tumour oxygenation. Nitro-L-arginine at 10 mg/kg i.v. increased Pi/total by 250% at 45 min and was maintained for at least 2 hr. Nitro-L-arginine also increased radiation resistance 3-5 fold, consistent with the induction of tumour hypoxia. The results indicate that tumour energy metabolism may be altered through drug induced modification of nitric oxide availability, and that these changes are sufficient to modify tumour sensitivity to X-rays. |
| doi_str_mv | 10.1006/bbrc.1993.1444 |
| format | Article |
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31P magnetic resonance spectroscopy, and on radiation sensitivity in the transplantable murine tumour, SCCVII/Ha. SIN-1 at 2 mg/kg i.v. reduced Pi/total by 40-50% within 10 min and increased X-ray sensitivity 3 fold, consistent with increased tumour oxygenation. Nitro-L-arginine at 10 mg/kg i.v. increased Pi/total by 250% at 45 min and was maintained for at least 2 hr. Nitro-L-arginine also increased radiation resistance 3-5 fold, consistent with the induction of tumour hypoxia. The results indicate that tumour energy metabolism may be altered through drug induced modification of nitric oxide availability, and that these changes are sufficient to modify tumour sensitivity to X-rays.</description><subject>Animals</subject><subject>Arginine - analogs & derivatives</subject><subject>Arginine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Cell Hypoxia</subject><subject>Energy Metabolism</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Molsidomine - analogs & derivatives</subject><subject>Molsidomine - pharmacology</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms, Experimental - metabolism</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitroarginine</subject><subject>Radiation Tolerance - drug effects</subject><subject>Tumors</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1r3DAQhkVpSTdpr70VdOjVW8n6sHUMS9IWsg2EFHozI2mcTvHKi-QN2X9fm11y62lg5nmHmYexT1KspRD2q_c5rKVzai211m_YSgonqloK_ZatxExUtZO_37PLUv4KIaW27oJdtLrVja1XLG_HSD0FmGhMfOz5TcL8dORbnMCPA5UdhxT5A0Q6IQ9Y9mMquLDAt4dMCfnjYTdm7o988wfSExZOif-kKVPg9y8UkV8_Aw3gaaDp-IG962Eo-PFcr9iv25vHzffq7v7bj831XRW00lNllLHosDHG11F58NYbaJ3qQaKRwZpGRWxqW7cgjFPS9lo56-euUs4IUFdsfdob8lhKxr7bZ9pBPnZSdIu7bnHXLe66xd0c-HwK7A9-h_EVP8ua51_OcygBhj5DClReMd00xsp2xtoThvNzz4S5K4EwBYyUMUxdHOl_F_wDuNaKjw</recordid><startdate>19930430</startdate><enddate>19930430</enddate><creator>Wood, P.J.</creator><creator>Stratford, I.J.</creator><creator>Adams, G.E.</creator><creator>Szabo, C.</creator><creator>Thiemermann, C.</creator><creator>Vane, J.R.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19930430</creationdate><title>Modification of Energy Metabolism and Radiation Response of a Murine Tumor by Changes in Nitric Oxide Availability</title><author>Wood, P.J. ; Stratford, I.J. ; Adams, G.E. ; Szabo, C. ; Thiemermann, C. ; Vane, J.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-5356e9e755b2d3bab6b5a893fa1e51c6573de72628a059316f4396b73d33950a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Arginine - analogs & derivatives</topic><topic>Arginine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Cell Hypoxia</topic><topic>Energy Metabolism</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Molsidomine - analogs & derivatives</topic><topic>Molsidomine - pharmacology</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Neoplasm Transplantation</topic><topic>Neoplasms, Experimental - metabolism</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitroarginine</topic><topic>Radiation Tolerance - drug effects</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wood, P.J.</creatorcontrib><creatorcontrib>Stratford, I.J.</creatorcontrib><creatorcontrib>Adams, G.E.</creatorcontrib><creatorcontrib>Szabo, C.</creatorcontrib><creatorcontrib>Thiemermann, C.</creatorcontrib><creatorcontrib>Vane, J.R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wood, P.J.</au><au>Stratford, I.J.</au><au>Adams, G.E.</au><au>Szabo, C.</au><au>Thiemermann, C.</au><au>Vane, J.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modification of Energy Metabolism and Radiation Response of a Murine Tumor by Changes in Nitric Oxide Availability</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1993-04-30</date><risdate>1993</risdate><volume>192</volume><issue>2</issue><spage>505</spage><epage>510</epage><pages>505-510</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>The nitric oxide donor, SIN-1 and nitric oxide synthase inhibitor, nitro-L-arginine were examined for their effects on energy metabolism using
31P magnetic resonance spectroscopy, and on radiation sensitivity in the transplantable murine tumour, SCCVII/Ha. SIN-1 at 2 mg/kg i.v. reduced Pi/total by 40-50% within 10 min and increased X-ray sensitivity 3 fold, consistent with increased tumour oxygenation. Nitro-L-arginine at 10 mg/kg i.v. increased Pi/total by 250% at 45 min and was maintained for at least 2 hr. Nitro-L-arginine also increased radiation resistance 3-5 fold, consistent with the induction of tumour hypoxia. The results indicate that tumour energy metabolism may be altered through drug induced modification of nitric oxide availability, and that these changes are sufficient to modify tumour sensitivity to X-rays.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>8484762</pmid><doi>10.1006/bbrc.1993.1444</doi><tpages>6</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1993-04, Vol.192 (2), p.505-510 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Arginine - analogs & derivatives Arginine - pharmacology Biological and medical sciences Biological Availability Cell Hypoxia Energy Metabolism Magnetic Resonance Spectroscopy Medical sciences Mice Mice, Inbred C3H Molsidomine - analogs & derivatives Molsidomine - pharmacology Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Transplantation Neoplasms, Experimental - metabolism Nitric Oxide - metabolism Nitroarginine Radiation Tolerance - drug effects Tumors |
| title | Modification of Energy Metabolism and Radiation Response of a Murine Tumor by Changes in Nitric Oxide Availability |
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