In Vivo Reversal of Glutathione Deficiency and Susceptibility to in Vivo Dexamethasone-Induced Apoptosis by N-Acetylcysteine and [formula omitted]-2-Oxothiazolidine- 4-carboxylic Acid, but Not Ascorbic Acid, in Thymocytes from γ-Glutamyltranspeptidase-Deficient Knockout Mice

Cellular glutathione is released during apoptosis and may play a role in the regulation of the mitochondrial permeability transition pore. The question of whether only cytosolic glutathione is important in apoptosis, or whether mitochondrial glutathione also plays a role, was investigated using γ-gl...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2002-01, Vol.397 (2), p.399-406
Hauptverfasser:	Will, Yvonne, Kaetzel, Rhonda S., Brown, Marda K., Fraley, Tamara S., Reed, Donald J.
Format:	Artikel
Sprache:	eng
Schlagworte:	[formula omitted]-2-oxothiazolidine-4-carboxylic acid apoptosis ascorbate dexamethasone flow cytometry glutathione knockout mice mitochondria N-acetylcysteine thymocytes
Online-Zugang:	Volltext
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