Transcriptional Regulation of 5-Aminolevulinate Synthase by Phenobarbital and cAMP-Dependent Protein Kinase

5-Aminolevulinate synthase (ALA-S) is a mitochondrial matrix enzyme that catalyzes the first and rate-limiting step of the heme biosynthesis. There are two ALA-S isozymes encoded by distinct genes. One gene encodes an isozyme that is expressed exclusively in erythroid cells, and the other gene encod...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1999-12, Vol.372 (2), p.261-270
Hauptverfasser:	Varone, Cecilia L, Giono, Luciana E, Ochoa, Alberto, Zakin, Mario M, Cánepa, Eduardo T
Format:	Artikel
Sprache:	eng
Schlagworte:	5-aminolevulinate synthase 5-Aminolevulinate Synthetase - genetics Animals Catalytic Domain Colforsin - pharmacology Cyclic AMP - analogs & derivatives Cyclic AMP - antagonists & inhibitors Cyclic AMP - metabolism Cyclic AMP - pharmacology Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Cyclic AMP-Dependent Protein Kinases - chemistry Cyclic AMP-Dependent Protein Kinases - genetics Cyclic AMP-Dependent Protein Kinases - metabolism Drug Synergism Enzyme Induction - drug effects gene expression heme biosynthesis Hemin - pharmacology Humans Isoenzymes - genetics Isoenzymes - metabolism Liver - cytology Liver - drug effects Liver - enzymology Male Mitochondria, Liver - drug effects Mitochondria, Liver - enzymology Mutation - genetics phenobarbital Phenobarbital - antagonists & inhibitors Phenobarbital - pharmacology Phosphorylation - drug effects Promoter Regions, Genetic - genetics protein kinase A Rats RNA, Messenger - genetics RNA, Messenger - metabolism Transcription, Genetic - drug effects Transcription, Genetic - genetics Tumor Cells, Cultured
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