Aldehyde Reductase: The Role of C-Terminal Residues in Defining Substrate and Cofactor Specificities

The only major structural difference between aldehyde reductase, a primarily NADPH-dependent aldo–keto reductase, and aldose reductase, a dually coenzyme-specific (NADPH/NADH) member of the same superfamily, is an additional eight amino acid residues in the substrate/inhibitor binding site (C-termin...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1998-07, Vol.355 (2), p.137-144
Hauptverfasser:	Rees-Milton, Karen J., Jia, Zongchao, Green, Nancy C., Bhatia, Mohit, El-Kabbani, Ossama, Flynn, T.Geoffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	aldehyde reductase Aldehyde Reductase - genetics Aldehyde Reductase - metabolism Aldehyde Reductase - physiology aldose reductase Amino Acid Sequence Amino Acid Substitution - genetics Animals Base Sequence C-terminus Kidney Kinetics Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed NAD - metabolism NADP - metabolism Oxidation-Reduction Peptide Fragments - genetics Peptide Fragments - metabolism Peptide Fragments - physiology Sequence Homology, Amino Acid Structure-Activity Relationship substrate specificity Substrate Specificity - genetics Swine
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