Phenoxyl Radical-Induced Thiol-Dependent Generation of Reactive Oxygen Species: Implications for Benzene Toxicity

Mechanisms of phenoxyl radical-induced generation of oxygen radicals potentially involved in toxicity of benzene were studied. We hypothesized that phenoxyl radical intermediates formed from phenolic metabolites of benzene by oxidative enzymes (e.g., peroxidases, tyrosinase) are able to damage biomo...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1995-03, Vol.317 (2), p.315-323
Hauptverfasser:	Stoyanovsky, D.A., Goldman, R., Claycamp, H.G., Kagan, V.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines - chemistry Benzene - metabolism Benzene - toxicity Chromatography, High Pressure Liquid Cyclic N-Oxides Deoxyguanosine - metabolism DNA - metabolism Electron Spin Resonance Spectroscopy Glutathione - metabolism Horseradish Peroxidase - metabolism Hydrogen Peroxide - metabolism Luminescent Measurements Monophenol Monooxygenase - metabolism Oxidation-Reduction Peroxidase - metabolism Phenol Phenols - metabolism Phenols - pharmacology Reactive Oxygen Species - metabolism Spin Labels Sulfhydryl Compounds - pharmacology Superoxides - analysis Superoxides - metabolism Thioctic Acid - analogs & derivatives Thioctic Acid - metabolism
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