Chemical constituents from the ethyl acetate extract of the stems of Macaranga balansae Gagnep

The genus Macaranga, one of the largest genera of the Euphorbiaceae family has approximately 300 species distributed in the tropical regions. Plants of this genus displayed various bioactivities such as antioxidant, antitumor and antimicrobial effects. Macaranga balansae Gagnep. is an endemic plant in Vietnam, that ethyl acetate extract showed cytotoxicity to cancer cell line. In this article, we report the isolation and structural elucidation of six known compounds from the ethyl acetate extract including (‐)‐dehydroxycubebin (1), trans‐coniferyl aldehyde (2), 3,3',4'‐tri‐O‐methyl ellagic acid (3), stigmastane 3β,5α,6β‐triol (4), 2,3‐dihydroxy‐1‐(4’‐hydroxy‐3’‐methoxyphenyl) propan‐1‐one (5), and protocatechuic acid (6). To the best of our knowledge, compounds 1‐5 were isolated from Macaranga genus for the first time.