The effects of ammonium perchlorate on thyroid homeostasis and thyroid-specific gene expression in rat

Perchlorate, a kind of inorganic chemical, is mainly used in defense industry and widely used in other civilian areas. It was well known that perchlorate exerts its thyrotoxicant effect on thyroid homeostasis via competitive inhibition of iodide uptake. However, some details of mechanism by which pe...

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Veröffentlicht in:	Environmental toxicology 2012-08, Vol.27 (8), p.445-452
Hauptverfasser:	Wu, Fenghong, Zhou, Xuan, Zhang, Rao, Pan, Meizhu, Peng, Kai-Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Body Weight - drug effects Ecotoxicology, biological effects of pollution Fundamental and applied biological sciences. Psychology Gene Expression - drug effects General aspects Homeostasis - drug effects Hypertrophy Iodide Peroxidase - genetics Iodide Peroxidase - metabolism Iodides - metabolism Iodine - deficiency Male perchlorate Perchlorates - toxicity Quaternary Ammonium Compounds - toxicity Rats Rats, Sprague-Dawley sodium/iodide symporter thyroglobulin Thyroglobulin - genetics Thyroglobulin - metabolism Thyroid Gland - drug effects Thyroid Gland - pathology thyroid homeostasis Thyroid Hormones - blood thyroid-specific gene thyroperoxidase
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