Effect of supplemental folic acid on valproic acid-induced embryotoxicity and tissue zinc levels in vivo

Valproic acid (VPA) is an anticonvulsant drug known to cause spina bifida in humans. Administration of the vitamin, folic acid has been reported to decrease the frequency of VPA‐induced exencephaly in mice treated with the drug in vivo. A protective effect by folinic acid has not been observed in vi...

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Veröffentlicht in:	Teratology (Philadelphia) 1995-11, Vol.52 (5), p.277-285
Hauptverfasser:	Hansen, Deborah K., Grafton, Thomas F., Dial, Stacey L., Gehring, Theresa A., Siitonen, Paul H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - toxicity Biological and medical sciences Circadian Rhythm Drug Interactions Drug toxicity and drugs side effects treatment Embryo, Mammalian - chemistry Embryonic and Fetal Development - drug effects Female Folic Acid - administration & dosage Folic Acid - blood Folic Acid - pharmacology Injections, Intraperitoneal Injections, Subcutaneous Male Medical sciences Mice Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Pregnancy Rats Tissue Distribution Valproic Acid - administration & dosage Valproic Acid - toxicity Zinc - chemistry
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