Activity profiles of developmental toxicity: Design considerations and pilot implementation

The available literature was searched for quantitative test results from both in vitro and in vivo assays for developmental toxicity for five model compounds: cyclophosphamide, methotrexate, hydroxyurea, caffeine, and ethylenethiourea. These compounds were chosen on the basis of their extensive util...

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Veröffentlicht in:	Teratology (Philadelphia) 1991-02, Vol.43 (2), p.159-185
Hauptverfasser:	Kavlock, Robert J., Greene, Jacqueline A., Kimmel, Gary L., Morrissey, Richard E., Owens, Elizabeth, Rogers, John M., Sadler, Thomas W., Stack, H. Frank, Waters, Michael D., Welsch, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Assay Caffeine - toxicity Cyclophosphamide - toxicity Data Collection Databases, Factual Drug toxicity and drugs side effects treatment Embryonic and Fetal Development - drug effects Ethylenethiourea - toxicity Humans Hydroxyurea - toxicity Medical sciences Methotrexate - toxicity Miscellaneous (drug allergy, mutagens, teratogens...) Mutagenicity Tests Pharmacology. Drug treatments Toxicology
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