Teratogenicity of paraxanthine (1,7-dimethylxanthine) in C57BL/6J mice

The teratogenicity of caffeine, as well as two of its three dimethylated metabolites (theobromine and theophylline), has been established in animal studies. The third metabolite, paraxanthine, has not been reported as being tested for teratogenicity even though it is actually the major demethylated...

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Veröffentlicht in:	Teratology (Philadelphia) 1986-12, Vol.34 (3), p.279-282
Hauptverfasser:	York, Raymond G., Randall, Joan L., Scott Jr, William J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced Animals Caffeine - toxicity Cleft Palate - chemically induced Dose-Response Relationship, Drug Female Limb Deformities, Congenital Maternal-Fetal Exchange Mice Mice, Inbred C57BL Pregnancy Theobromine - toxicity Theophylline - toxicity
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