Metal-salt potentiation of salicylate-induced teratogenesis and behavioral changes in rats

The effects of parenteral metal supplements on salicylate teratogenicity were studied in rats. Ferrous gluconate (16 mg/kg), manganous sulfate (10 mg/kg), cuprous sulfate (6 mg/kg), or deionized water were given ip on days 8, 9, and 10 of gestation, Sodium salicylate (250 or 500 mg/kg) or deionized...

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Veröffentlicht in:	Teratology (Philadelphia) 1974-12, Vol.10 (3), p.293-300
Hauptverfasser:	Kimmel, Carole A., Butcher, Richard E., Vorhees, Charles V., Schumacher, Herbert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced Animals Behavior, Animal - drug effects Chelating Agents Copper - pharmacology Drug Interactions Drug Synergism Female Fetus - drug effects Gestational Age Iron - pharmacology Male Manganese - pharmacology Maternal-Fetal Exchange Pregnancy Protein Binding Rats Sodium Salicylate - blood Sodium Salicylate - metabolism Sodium Salicylate - toxicity Sulfates - pharmacology
Online-Zugang:	Volltext
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