Teratogenic action of acetazolamide in golden hamsters

The carbonic‐anhydrase inhibitor acetazolamide was teratogenic for golden hamsters when given in single intraperitoneal doses of from 300‐1200 mg/kg on the 9th day of pregnancy. Most deformities were of the postaxial part of the forelimb. There was a well‐defined dose‐response relation with an ED50...

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Veröffentlicht in:	Teratology (Philadelphia) 1971-02, Vol.4 (1), p.95-101
1. Verfasser:	Layton Jr, W. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced - etiology Acetazolamide - administration & dosage Acetazolamide - metabolism Acetazolamide - pharmacology Acetazolamide - toxicity Animals Body Weight - drug effects Brain - abnormalities Carbonic Anhydrase Inhibitors
Online-Zugang:	Volltext
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