Adverse effects of prenatal methimazole exposure
Background A specific phenotype of methimazole (MMI) induced malformations has recently been postulated. MMI embryopathy is characterized by minor dysmorphic features, choanal atresia and/or esophageal atresia, growth retardation, and developmental delay. Methods We prospectively studied the outcome...
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| Veröffentlicht in: | Teratology (Philadelphia) 2001-11, Vol.64 (5), p.262-266 |
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| creator | Di Gianantonio, Elena Schaefer, Christof Mastroiacovo, Pier P. Cournot, Marie P. Benedicenti, Francesco Reuvers, Minke Occupati, Brunella Robert, Elisabeth Bellemin, Beatrice Addis, Antonio Arnon, Judy Clementi, Maurizio |
| description | Background
A specific phenotype of methimazole (MMI) induced malformations has recently been postulated. MMI embryopathy is characterized by minor dysmorphic features, choanal atresia and/or esophageal atresia, growth retardation, and developmental delay.
Methods
We prospectively studied the outcome of pregnancy in 241 women counseled by 10 Teratology Information Services (TIS) of the European Network of Teratology Information Services (ENTIS) because of MMI exposure, and compared them with those of 1,089 pregnant women referred to TIS because of exposure to nonteratogenic drugs (control group). Information was obtained by mail or telephone interview.
Results
There was no increase in the general rate of major anomalies or of spontaneous or induced abortions in the MMI‐exposed group in comparison with the control group. Two newborns were affected with one of the major malformations that are part of the postulated embryopathy.
Conclusions
The results of this study indicate that choanal as well as esophageal atresia may have a higher incidence than expected in fetuses exposed to MMI between 3 and 7 gestational weeks. Until further data are available, thyrotoxicosis should be treated with propylthiouracil, as it is apparently safer for use during the fertile period. Teratology 64:262–266, 2001. © 2001 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/tera.1072 |
| format | Article |
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A specific phenotype of methimazole (MMI) induced malformations has recently been postulated. MMI embryopathy is characterized by minor dysmorphic features, choanal atresia and/or esophageal atresia, growth retardation, and developmental delay.
Methods
We prospectively studied the outcome of pregnancy in 241 women counseled by 10 Teratology Information Services (TIS) of the European Network of Teratology Information Services (ENTIS) because of MMI exposure, and compared them with those of 1,089 pregnant women referred to TIS because of exposure to nonteratogenic drugs (control group). Information was obtained by mail or telephone interview.
Results
There was no increase in the general rate of major anomalies or of spontaneous or induced abortions in the MMI‐exposed group in comparison with the control group. Two newborns were affected with one of the major malformations that are part of the postulated embryopathy.
Conclusions
The results of this study indicate that choanal as well as esophageal atresia may have a higher incidence than expected in fetuses exposed to MMI between 3 and 7 gestational weeks. Until further data are available, thyrotoxicosis should be treated with propylthiouracil, as it is apparently safer for use during the fertile period. Teratology 64:262–266, 2001. © 2001 Wiley‐Liss, Inc.</description><identifier>ISSN: 0040-3709</identifier><identifier>EISSN: 1096-9926</identifier><identifier>DOI: 10.1002/tera.1072</identifier><identifier>PMID: 11745832</identifier><identifier>CODEN: TJADAB</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Abnormalities, Drug-Induced - diagnosis ; Abortion, Spontaneous ; Adult ; Age Factors ; Biological and medical sciences ; Body Weight ; Cohort Studies ; Developmental Disabilities - chemically induced ; Drug toxicity and drugs side effects treatment ; Esophageal Atresia - chemically induced ; Europe ; Female ; Humans ; Infant, Newborn ; Information Services ; Male ; Medical sciences ; Methimazole - adverse effects ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Pharmacology. Drug treatments ; Phenotype ; Pregnancy ; Pregnancy Trimester, First ; Prospective Studies ; Teratogens ; Time Factors</subject><ispartof>Teratology (Philadelphia), 2001-11, Vol.64 (5), p.262-266</ispartof><rights>Copyright © 2001 Wiley‐Liss, Inc.</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2001 Wiley-Liss, Inc.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4902-94159e8e026000d56aa9637868a0cee1b2337e88f79f25e665b21255f8cc48e93</citedby><cites>FETCH-LOGICAL-c4902-94159e8e026000d56aa9637868a0cee1b2337e88f79f25e665b21255f8cc48e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Ftera.1072$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Ftera.1072$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14058570$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11745832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Di Gianantonio, Elena</creatorcontrib><creatorcontrib>Schaefer, Christof</creatorcontrib><creatorcontrib>Mastroiacovo, Pier P.</creatorcontrib><creatorcontrib>Cournot, Marie P.</creatorcontrib><creatorcontrib>Benedicenti, Francesco</creatorcontrib><creatorcontrib>Reuvers, Minke</creatorcontrib><creatorcontrib>Occupati, Brunella</creatorcontrib><creatorcontrib>Robert, Elisabeth</creatorcontrib><creatorcontrib>Bellemin, Beatrice</creatorcontrib><creatorcontrib>Addis, Antonio</creatorcontrib><creatorcontrib>Arnon, Judy</creatorcontrib><creatorcontrib>Clementi, Maurizio</creatorcontrib><title>Adverse effects of prenatal methimazole exposure</title><title>Teratology (Philadelphia)</title><addtitle>Teratology</addtitle><description>Background
A specific phenotype of methimazole (MMI) induced malformations has recently been postulated. MMI embryopathy is characterized by minor dysmorphic features, choanal atresia and/or esophageal atresia, growth retardation, and developmental delay.
Methods
We prospectively studied the outcome of pregnancy in 241 women counseled by 10 Teratology Information Services (TIS) of the European Network of Teratology Information Services (ENTIS) because of MMI exposure, and compared them with those of 1,089 pregnant women referred to TIS because of exposure to nonteratogenic drugs (control group). Information was obtained by mail or telephone interview.
Results
There was no increase in the general rate of major anomalies or of spontaneous or induced abortions in the MMI‐exposed group in comparison with the control group. Two newborns were affected with one of the major malformations that are part of the postulated embryopathy.
Conclusions
The results of this study indicate that choanal as well as esophageal atresia may have a higher incidence than expected in fetuses exposed to MMI between 3 and 7 gestational weeks. Until further data are available, thyrotoxicosis should be treated with propylthiouracil, as it is apparently safer for use during the fertile period. Teratology 64:262–266, 2001. © 2001 Wiley‐Liss, Inc.</description><subject>Abnormalities, Drug-Induced - diagnosis</subject><subject>Abortion, Spontaneous</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Cohort Studies</subject><subject>Developmental Disabilities - chemically induced</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Esophageal Atresia - chemically induced</subject><subject>Europe</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Information Services</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methimazole - adverse effects</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenotype</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Prospective Studies</subject><subject>Teratogens</subject><subject>Time Factors</subject><issn>0040-3709</issn><issn>1096-9926</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1j01PAjEQhhujEUQP_gHDxYOHlWm7_ToSgvhBNCGIx6Ys07i6sKRdFPz1LoHIydNMMs87Mw8hlxRuKQDrVBhc3Sl2RJoUjEyMYfKYNAFSSLgC0yBnMX4AUKCUn5IGpSoVmrMmge7sC0PENnqPWRXbpW8vAy5c5Yr2HKv3fO5-yqKer5dlXAU8JyfeFREv9rVFXu_64959MnwZPPS6wyRLDbDEpFQY1AhMAsBMSOeM5EpL7SBDpFPGuUKtvTKeCZRSTBllQnidZalGw1vkZrc3C2WMAb1dhvqXsLEU7Nbabq3t1rpmr3bscjWd4-xA7jVr4HoPuJi5wge3yPJ44FIQWiiouc6O-84L3Px_0Y77o-7-dLJL5LHC9V_ChU8rFVfCvj0P7ISNgD-KiX3iv20xfBU</recordid><startdate>200111</startdate><enddate>200111</enddate><creator>Di Gianantonio, Elena</creator><creator>Schaefer, Christof</creator><creator>Mastroiacovo, Pier P.</creator><creator>Cournot, Marie P.</creator><creator>Benedicenti, Francesco</creator><creator>Reuvers, Minke</creator><creator>Occupati, Brunella</creator><creator>Robert, Elisabeth</creator><creator>Bellemin, Beatrice</creator><creator>Addis, Antonio</creator><creator>Arnon, Judy</creator><creator>Clementi, Maurizio</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200111</creationdate><title>Adverse effects of prenatal methimazole exposure</title><author>Di Gianantonio, Elena ; Schaefer, Christof ; Mastroiacovo, Pier P. ; Cournot, Marie P. ; Benedicenti, Francesco ; Reuvers, Minke ; Occupati, Brunella ; Robert, Elisabeth ; Bellemin, Beatrice ; Addis, Antonio ; Arnon, Judy ; Clementi, Maurizio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4902-94159e8e026000d56aa9637868a0cee1b2337e88f79f25e665b21255f8cc48e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Abnormalities, Drug-Induced - diagnosis</topic><topic>Abortion, Spontaneous</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Cohort Studies</topic><topic>Developmental Disabilities - chemically induced</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Esophageal Atresia - chemically induced</topic><topic>Europe</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Information Services</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methimazole - adverse effects</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenotype</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Prospective Studies</topic><topic>Teratogens</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Di Gianantonio, Elena</creatorcontrib><creatorcontrib>Schaefer, Christof</creatorcontrib><creatorcontrib>Mastroiacovo, Pier P.</creatorcontrib><creatorcontrib>Cournot, Marie P.</creatorcontrib><creatorcontrib>Benedicenti, Francesco</creatorcontrib><creatorcontrib>Reuvers, Minke</creatorcontrib><creatorcontrib>Occupati, Brunella</creatorcontrib><creatorcontrib>Robert, Elisabeth</creatorcontrib><creatorcontrib>Bellemin, Beatrice</creatorcontrib><creatorcontrib>Addis, Antonio</creatorcontrib><creatorcontrib>Arnon, Judy</creatorcontrib><creatorcontrib>Clementi, Maurizio</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Teratology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Di Gianantonio, Elena</au><au>Schaefer, Christof</au><au>Mastroiacovo, Pier P.</au><au>Cournot, Marie P.</au><au>Benedicenti, Francesco</au><au>Reuvers, Minke</au><au>Occupati, Brunella</au><au>Robert, Elisabeth</au><au>Bellemin, Beatrice</au><au>Addis, Antonio</au><au>Arnon, Judy</au><au>Clementi, Maurizio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adverse effects of prenatal methimazole exposure</atitle><jtitle>Teratology (Philadelphia)</jtitle><addtitle>Teratology</addtitle><date>2001-11</date><risdate>2001</risdate><volume>64</volume><issue>5</issue><spage>262</spage><epage>266</epage><pages>262-266</pages><issn>0040-3709</issn><eissn>1096-9926</eissn><coden>TJADAB</coden><abstract>Background
A specific phenotype of methimazole (MMI) induced malformations has recently been postulated. MMI embryopathy is characterized by minor dysmorphic features, choanal atresia and/or esophageal atresia, growth retardation, and developmental delay.
Methods
We prospectively studied the outcome of pregnancy in 241 women counseled by 10 Teratology Information Services (TIS) of the European Network of Teratology Information Services (ENTIS) because of MMI exposure, and compared them with those of 1,089 pregnant women referred to TIS because of exposure to nonteratogenic drugs (control group). Information was obtained by mail or telephone interview.
Results
There was no increase in the general rate of major anomalies or of spontaneous or induced abortions in the MMI‐exposed group in comparison with the control group. Two newborns were affected with one of the major malformations that are part of the postulated embryopathy.
Conclusions
The results of this study indicate that choanal as well as esophageal atresia may have a higher incidence than expected in fetuses exposed to MMI between 3 and 7 gestational weeks. Until further data are available, thyrotoxicosis should be treated with propylthiouracil, as it is apparently safer for use during the fertile period. Teratology 64:262–266, 2001. © 2001 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11745832</pmid><doi>10.1002/tera.1072</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abnormalities, Drug-Induced - diagnosis Abortion, Spontaneous Adult Age Factors Biological and medical sciences Body Weight Cohort Studies Developmental Disabilities - chemically induced Drug toxicity and drugs side effects treatment Esophageal Atresia - chemically induced Europe Female Humans Infant, Newborn Information Services Male Medical sciences Methimazole - adverse effects Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Phenotype Pregnancy Pregnancy Trimester, First Prospective Studies Teratogens Time Factors |
| title | Adverse effects of prenatal methimazole exposure |
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