Hyperploid cells in the limb buds of rats and 5-azacytidine-induced digital deformities

To clarify the mechanism underlying the digital teratogenesis of 5‐azacytidine (5‐AC), the DNA contents of mesenchymal cells were examined in the limb buds of the rat by microspectrophotometry. 5‐AC induced hyperploid cells: 2.4% at 18 h after injection and 3.2% at 24 h. No hyperploid cells were not...

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Veröffentlicht in:	Teratogenesis, carcinogenesis, and mutagenesis carcinogenesis, and mutagenesis, 1991, Vol.11 (5), p.259-265
Hauptverfasser:	Kurishita, Akihiro, Ihara, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced - embryology Abnormalities, Drug-Induced - etiology Abnormalities, Drug-Induced - genetics Abnormalities, Drug-Induced - prevention & control Animals Azacitidine - antagonists & inhibitors Azacitidine - toxicity Biological and medical sciences caffeine Caffeine - pharmacology cell death Drug toxicity and drugs side effects treatment Female Hindlimb - abnormalities Hindlimb - embryology Humans Male Medical sciences mesenchymal cells microspectrophotometry Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Polyploidy Rats Rats, Inbred Strains - embryology Specific Pathogen-Free Organisms Toes - abnormalities Toes - embryology
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