Alpha 4 nicotinic acetylcholine receptor subunit links cholinergic to brainstem monoaminergic neurotransmission

Agonists of nicotinic receptors containing the α4‐subunit produce antinociception accompanied by several adverse side effects. The purpose of this study was to determine the distribution of the α4‐subunit of nicotinic acetylcholine receptors (nAChR) in brainstem monoaminergic nuclei that may contrib...

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Veröffentlicht in:	Synapse (New York, N.Y.) N.Y.), 2003-09, Vol.49 (3), p.195-205
Hauptverfasser:	Cucchiaro, Giovanni, Commons, Kathryn G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biogenic Monoamines - analysis Brain Stem - chemistry Brain Stem - drug effects Brain Stem - metabolism Bridged Bicyclo Compounds, Heterocyclic - pharmacology Bridged Bicyclo Compounds, Heterocyclic - toxicity Dopamine - analysis dorsal raphe Dose-Response Relationship, Drug epibatidine Fluorescent Antibody Technique Immunohistochemistry locus coeruleus Male Neurons - chemistry Neurons - drug effects Neurons - metabolism Nicotinic Agonists - pharmacology Nicotinic Agonists - toxicity Norepinephrine - analysis nucleus raphe magnus Proto-Oncogene Proteins c-fos - metabolism Pyridines - pharmacology Pyridines - toxicity Rats Rats, Sprague-Dawley Receptors, Nicotinic - analysis Serotonin - analysis Tyrosine 3-Monooxygenase - analysis α4-nAChR
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