TAp63 Is Important for Cardiac Differentiation of Embryonic Stem Cells and Heart Development

p63, a member of the p53 family, is essential for skin morphogenesis and epithelial stem cell maintenance. Here, we report an unexpected role of TAp63 in cardiogenesis. p63 null mice exhibit severe defects in embryonic cardiac development, including dilation of both ventricles, a defect in trabecula...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2011-11, Vol.29 (11), p.1672-1683
Hauptverfasser:	Rouleau, Matthieu, Medawar, Alain, Hamon, Laurent, Shivtiel, Shoham, Wolchinsky, Zohar, Zhou, Huiqing, De Rosa, Laura, Candi, Eleonora, de la Forest Divonne, Stéphanie, Mikkola, Marja L., van Bokhoven, Hans, Missero, Caterina, Melino, Gerry, Pucéat, Michel, Aberdam, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiogenesis Cardiomyopathy Cell Differentiation - genetics Cell Differentiation - physiology Cell Line Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Embryonic Stem Cells - ultrastructure Flow Cytometry Fluorescent Antibody Technique GATA GATA6 Transcription Factor - genetics GATA6 Transcription Factor - metabolism Heart - embryology Heart - growth & development HMGB Proteins - genetics HMGB Proteins - metabolism Immunoblotting Mice Mice, Knockout Microscopy, Electron, Transmission p63 Phosphoproteins - genetics Phosphoproteins - metabolism Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction sox17 SOXF Transcription Factors - genetics SOXF Transcription Factors - metabolism Trans-Activators - genetics Trans-Activators - metabolism trp63
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