The Pathology of Bleomycin‐Induced Fibrosis Is Associated with Loss of Resident Lung Mesenchymal Stem Cells That Regulate Effector T‐cell Proliferation

Tissue‐resident mesenchymal stem cells (MSCs) are important regulators of tissue repair or regeneration, fibrosis, inflammation, angiogenesis, and tumor formation. Here, we define a population of resident lung MSCs (luMSCs) that function to regulate the severity of bleomycin injury via modulation of...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2011-04, Vol.29 (4), p.725-735
Hauptverfasser:	Jun, Du, Garat, Chrystelle, West, James, Thorn, Nathalie, Chow, Kelsey, Cleaver, Timothy, Sullivan, Timothy, Torchia, Enrique C., Childs, Christine, Shade, Theodore, Tadjali, Mehrdad, Lara, Abigail, Nozik‐Grayck, Eva, Malkoski, Stephen, Sorrentino, Brian, Meyrick, Barbara, Klemm, Dwight, Rojas, Mauricio, Wagner, David H., Majka, Susan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bleomycin - adverse effects Bleomycin - pharmacology Cell Proliferation Familial Primary Pulmonary Hypertension Hypertension, Pulmonary - pathology Lung Injury Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - drug effects Mice Mice, Inbred C57BL Polymerase Chain Reaction Pulmonary fibrosis Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - pathology Pulmonary hypertension Resident lung mesenchymal stem cells Stem cells T-Lymphocytes - cytology
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