Early Suppressive Effects of Chemotherapy on Recovery of Bone Marrow Megakaryocyte Precursors: Possible Relationship to Platelet Recovery

This study utilized a recently developed culture and quantitation system to detect megakaryocyte precursors in CD34+ bone marrow cells from normal donors and breast cancer patients treated with 5‐fluorouracil, leucovorin, adriamycin and cyclophosphamide (FLAC). Bone marrow was obtained from patients...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 1996, Vol.14 (S1), p.31-37
Hauptverfasser:	Warren, M. Kim, Zujewski, Joanne, Rose, Wendy L., Szabo, Janet M., O'Shaughnessy, Joyce A., Halverson, David C., Cowan, Kenneth H., Gress, Ronald E., Schwartz, Gretchen N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD34 - biosynthesis Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Blood Cell Count Blood Platelets - drug effects Bone Marrow Cells - drug effects Breast Neoplasms - drug therapy Case-Control Studies CD34+ cells Chemotherapy Cyclophosphamide - therapeutic use Doxorubicin - therapeutic use ELISA Enzyme-Linked Immunosorbent Assay Female Fluorouracil - therapeutic use Glycoprotein GPIIb/IIIa Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Humans Interleukin-3 - metabolism Interleukin-3 - pharmacology Leucovorin - therapeutic use Megakaryocytes Megakaryocytes - metabolism Megakaryocytes - physiology Platelet Glycoprotein GPIIb-IIIa Complex - biosynthesis Recombinant Fusion Proteins - pharmacology Stem Cell Factor - metabolism Thrombocytopenia - etiology Time Factors
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