Effect of alpha- and gamma-Interferon and tumor necrosis factor on colony formation of two human renal tumor xenografts in vitro

The in vitro antitumor activity of alpha‐ and gamma‐interferon as well as tumor necrosis factor was tested on two human renal cell carcinoma xenografts—RC‐43 and NC‐65. A dose‐dependent inhibition of colony formation in soft agar was found for both tumor lines. NC‐65, however, showed no sensitivity...

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Veröffentlicht in:	Seminars in surgical oncology 1988, Vol.4 (3), p.195-198
Hauptverfasser:	Beniers, A. J. M. C., Peelen, W. P., Hendriks, B. Th, Schalken, J. A., Debruyne, F. M. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carcinoma, Renal Cell - therapy Cell Line, Transformed Dose-Response Relationship, Drug Drug Synergism Humans IFN Interferon Type I - administration & dosage Interferon-gamma - administration & dosage Kidney Neoplasms - therapy Mice Mice, Inbred BALB C Recombinant Proteins renal tumor soft agar TNF Tumor Necrosis Factor-alpha - administration & dosage Tumor Stem Cell Assay xenograft
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