Effect of alpha- and gamma-Interferon and tumor necrosis factor on colony formation of two human renal tumor xenografts in vitro
The in vitro antitumor activity of alpha‐ and gamma‐interferon as well as tumor necrosis factor was tested on two human renal cell carcinoma xenografts—RC‐43 and NC‐65. A dose‐dependent inhibition of colony formation in soft agar was found for both tumor lines. NC‐65, however, showed no sensitivity...
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| Veröffentlicht in: | Seminars in surgical oncology 1988, Vol.4 (3), p.195-198 |
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| container_title | Seminars in surgical oncology |
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| creator | Beniers, A. J. M. C. Peelen, W. P. Hendriks, B. Th Schalken, J. A. Debruyne, F. M. J. |
| description | The in vitro antitumor activity of alpha‐ and gamma‐interferon as well as tumor necrosis factor was tested on two human renal cell carcinoma xenografts—RC‐43 and NC‐65. A dose‐dependent inhibition of colony formation in soft agar was found for both tumor lines. NC‐65, however, showed no sensitivity for gamma‐interferon. Combination drug tests showed a synergistic effect on colony formation of both tumor lines. The strongest inhibition was shown by the combination of alpha‐interferon and tumor necrosis factor. We conclude that both interferons as well as tumor necrosis factor show direct in vitro cytostatic effects against renal tumor direct in vitro cytostatic effects against renal tumor cells. |
| doi_str_mv | 10.1002/ssu.2980040311 |
| format | Article |
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J. M. C.</creatorcontrib><creatorcontrib>Peelen, W. P.</creatorcontrib><creatorcontrib>Hendriks, B. Th</creatorcontrib><creatorcontrib>Schalken, J. A.</creatorcontrib><creatorcontrib>Debruyne, F. M. J.</creatorcontrib><title>Effect of alpha- and gamma-Interferon and tumor necrosis factor on colony formation of two human renal tumor xenografts in vitro</title><title>Seminars in surgical oncology</title><addtitle>Semin. Surg. Oncol</addtitle><description>The in vitro antitumor activity of alpha‐ and gamma‐interferon as well as tumor necrosis factor was tested on two human renal cell carcinoma xenografts—RC‐43 and NC‐65. A dose‐dependent inhibition of colony formation in soft agar was found for both tumor lines. NC‐65, however, showed no sensitivity for gamma‐interferon. Combination drug tests showed a synergistic effect on colony formation of both tumor lines. The strongest inhibition was shown by the combination of alpha‐interferon and tumor necrosis factor. We conclude that both interferons as well as tumor necrosis factor show direct in vitro cytostatic effects against renal tumor direct in vitro cytostatic effects against renal tumor cells.</description><subject>Animals</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Carcinoma, Renal Cell - therapy</subject><subject>Cell Line, Transformed</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Synergism</subject><subject>Humans</subject><subject>IFN</subject><subject>Interferon Type I - administration & dosage</subject><subject>Interferon-gamma - administration & dosage</subject><subject>Kidney Neoplasms - therapy</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Recombinant Proteins</subject><subject>renal tumor</subject><subject>soft agar</subject><subject>TNF</subject><subject>Tumor Necrosis Factor-alpha - administration & dosage</subject><subject>Tumor Stem Cell Assay</subject><subject>xenograft</subject><issn>8756-0437</issn><issn>1098-2388</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFPGzEQhS3UiobAlVsl_4ENY3s33j1WlAASgkMaVeJizXpt2HbXjmynkFt_OoZEVJx6Gs28-Z5mHiGnDGYMgJ_FuJnxpgYoQTB2QCYMmrrgoq4_kUktq3kBpZBfyFGMvwAYq7g4JIeClRygmZC_F9Yanai3FIf1IxYUXUcfcByxuHbJBGuCd2_DtBl9oM7o4GMfqUWdcp9F7QfvttT6MGLq8yCbpSdPHzcjOhqMw2EPPxvnHwLaFGnv6J8-BX9MPlscojnZ1ylZLS5-nF8VN3eX1-ffbgrNG8EKK_J7nQSUvOy0EFLLSooWGqGNlEKjaSvTQINVCxqxxrKzcztvc5GcaxBTMtv5vp4fg7FqHfoRw1YxUK9Jqpyk-pdkBr7ugPWmHU33vr6PLuvNTn_qB7P9j5taLlcfvIsd28dknt9ZDL_VXApZqZ-3l0rc339fLuRCLcQLzaaRjw</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Beniers, A. 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J. M. C.</creatorcontrib><creatorcontrib>Peelen, W. P.</creatorcontrib><creatorcontrib>Hendriks, B. Th</creatorcontrib><creatorcontrib>Schalken, J. A.</creatorcontrib><creatorcontrib>Debruyne, F. M. J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Seminars in surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beniers, A. J. M. C.</au><au>Peelen, W. P.</au><au>Hendriks, B. Th</au><au>Schalken, J. A.</au><au>Debruyne, F. M. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of alpha- and gamma-Interferon and tumor necrosis factor on colony formation of two human renal tumor xenografts in vitro</atitle><jtitle>Seminars in surgical oncology</jtitle><addtitle>Semin. Surg. Oncol</addtitle><date>1988</date><risdate>1988</risdate><volume>4</volume><issue>3</issue><spage>195</spage><epage>198</epage><pages>195-198</pages><issn>8756-0437</issn><eissn>1098-2388</eissn><abstract>The in vitro antitumor activity of alpha‐ and gamma‐interferon as well as tumor necrosis factor was tested on two human renal cell carcinoma xenografts—RC‐43 and NC‐65. A dose‐dependent inhibition of colony formation in soft agar was found for both tumor lines. NC‐65, however, showed no sensitivity for gamma‐interferon. Combination drug tests showed a synergistic effect on colony formation of both tumor lines. The strongest inhibition was shown by the combination of alpha‐interferon and tumor necrosis factor. We conclude that both interferons as well as tumor necrosis factor show direct in vitro cytostatic effects against renal tumor direct in vitro cytostatic effects against renal tumor cells.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>3142009</pmid><doi>10.1002/ssu.2980040311</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8756-0437 |
| ispartof | Seminars in surgical oncology, 1988, Vol.4 (3), p.195-198 |
| issn | 8756-0437 1098-2388 |
| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Animals Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carcinoma, Renal Cell - therapy Cell Line, Transformed Dose-Response Relationship, Drug Drug Synergism Humans IFN Interferon Type I - administration & dosage Interferon-gamma - administration & dosage Kidney Neoplasms - therapy Mice Mice, Inbred BALB C Recombinant Proteins renal tumor soft agar TNF Tumor Necrosis Factor-alpha - administration & dosage Tumor Stem Cell Assay xenograft |
| title | Effect of alpha- and gamma-Interferon and tumor necrosis factor on colony formation of two human renal tumor xenografts in vitro |
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