Development of Highly Efficient Dual‐AAV Split Adenosine Base Editor for In Vivo Gene Therapy

The adenosine base editor (ABE) is able to catalyze A•T to C•G conversion efficiently and precisely in vivo, representing a new method for gene therapy. Adeno associated virus (AAV) is a well‐studied vector for gene delivery in vivo. However, due to the limited loading capacity of AAV vector (≈4800...

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Veröffentlicht in:	Small methods 2020-09, Vol.4 (9), p.n/a
Hauptverfasser:	Chen, Yuxi, Zhi, Shengyao, Liu, Weiliang, Wen, Jinkun, Hu, Sihui, Cao, Tianqi, Sun, Hongwei, Li, Yang, Huang, Li, Liu, Yizhi, Liang, Puping, Huang, Junjiu
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine base editors adeno‐associated viruses gene editing gene therapy split‐ABE
Online-Zugang:	Volltext
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