Fe III -Doped Two-Dimensional C 3 N 4 Nanofusiform: A New O 2 -Evolving and Mitochondria-Targeting Photodynamic Agent for MRI and Enhanced Antitumor Therapy

Local hypoxia in tumors, as well as the short lifetime and limited action region of O , are undesirable impediments for photodynamic therapy (PDT), leading to a greatly reduced effectiveness. To overcome these adversities, a mitochondria-targeting, H O -activatable, and O -evolving PDT nanoplatform...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2016-10, Vol.12 (39), p.5477-5487
Hauptverfasser:	Ma, Zhifang, Zhang, Mengchao, Jia, Xiaodan, Bai, Jing, Ruan, Yudi, Wang, Chao, Sun, Xuping, Jiang, Xiue
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Catalysis Cell Survival - drug effects Female HeLa Cells Humans Hydrogen Peroxide - pharmacology Iron - chemistry Magnetic Resonance Imaging Membrane Potential, Mitochondrial - drug effects Methylene Blue - chemistry Methylene Blue - pharmacology Mice Mitochondria - drug effects Mitochondria - metabolism Nanoparticles - chemistry Oxygen - analysis Photochemotherapy Photosensitizing Agents - pharmacology Superoxides - chemistry Theranostic Nanomedicine
Online-Zugang:	Volltext
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