Pronounced Anti‐Inflammatory and Analgesic Activities of a Spirofuran‐Triazolo[1,5‐a]pyrimidine Scaffold Available via Biginelli Multicomponent Condensation

In this work, a series of phenyl‐derivatives of spirofuran‐triazolo[1,5‐a]pyrimidine (5 a–i) were evaluated for their anti‐inflammatory and analgesic activities, including SAR and molecular docking studies. The cytotoxicity of compounds was studied in RAW 264.7 murine macrophage cell line by MTT ass...

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Veröffentlicht in:	ChemistrySelect (Weinheim) 2024-09, Vol.9 (36), p.n/a
Hauptverfasser:	Gümüş, Mustafa Kemal, Doğan, İnci Selin, Reis, Rengin, Sipahi, Hande, Uba, Abdullahi Ibrahim, Gorobets, Mykola Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory activity Biginelli reaction Molecular docking MTT assay PGE2
Online-Zugang:	Volltext
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