Design and Synthesis of β‐O‐Glucosylated 5‐(Arylidene)‐6‐Aminouracils: Towards Water‐Soluble 8‐Aryl Xanthines as Effective Enzyme Inhibitors

8‐Aryl xanthines are selective enzyme inhibitors modified from naturally occurring methylxanthines. However, the low water solubility of substituted xanthines restricts their clinical applications. We developed a strategy to improve the water solubility of biologically privileged 8‐aryl xanthines. A...

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Veröffentlicht in:	ChemistrySelect (Weinheim) 2024-07, Vol.9 (26), p.n/a
Hauptverfasser:	Poslu, Ayşe Halıç, Ertik, Onur, Abul, Nurgül, Telli, Fatma Çetin, Gülçin, İlhami, Koz, Ömer, Koz, Gamze
Format:	Artikel
Sprache:	eng
Schlagworte:	8-aryl xanthine Enzymes Glucosylation Molecular docking Nitrogen heterocycles
Online-Zugang:	Volltext
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