Cytotoxic Performance of Synthesized Mn‐Doped ZnO Nanorods in MCF‐7 Cells

This report presents the outcomes of exerting extracted Salvadora persica for synthesizing ZnO nanoparticles (ZnO−NP) and Mn‐doped ZnO nanorods (Mn−ZnO−NRs) through a viable and economical “green” route. The products characteristics were configured by the means of X‐ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy‐dispersive X‐ray (EDX) spectroscopy, UV‐visible spectroscopy (UV‐Vis) and Raman assessing technics. As the constructional evaluations approved the progress of well crystalline nano, the EDX analyses approved the doping of Mn, which interestingly succeeded in significantly altering the spherical framework of ZnO into a rod‐looking structure. The following steps involved the employment of MTT trial to assay the cytotoxic impacts of our sample towards breast (MCF‐7: Michigan Cancer Foundation‐7) cancer cell line, resulting in confirming the superior outcomes of Mn−ZnO−NRs than the solitary case of ZnO. The boosted functionality of the doped product may be attributable to the appearance of Mn into the lattice of ZnO. In addition, the evolved morphology of ZnO, obtained through the doping process, could have caused substantial developments in the cytotoxic operation of doped sample as well. In this study, Mn doped ZnO nanorods were prepared using by the usage of Salvadora persica, through an easy, fast, inexpensive, and eco‐friendly way. After characterization of prepared nanoparticles, their cytotoxic activity was studied. We also appraised the toxic performance of our synthesized product towards MCF‐7 cell line and affirmed the superior inhibitory impact of 5 % Mn−ZnO−NRs than the case of ZnO−NP. As another interesting fact, the doping of Mn into the construction of ZnO−NP empowered its cytotoxic dominance.