Applications of Wittig Reaction in the Total Synthesis of Natural Macrolides
The Wittig reaction involves the synthesis of an alkene via the conversion of an aldehyde or ketone with the already generated ylide from a phosphonium salt. Significantly, when this important name reaction is employed the desired alkenes are constructed via a predictable manner, thus resultant part...
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| Veröffentlicht in: | ChemistrySelect (Weinheim) 2020-08, Vol.5 (31), p.9654-9690 |
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| creator | Heravi, Majid M. Zadsirjan, Vahideh Daraie, Mansoureh Ghanbarian, Manizheh |
| description | The Wittig reaction involves the synthesis of an alkene via the conversion of an aldehyde or ketone with the already generated ylide from a phosphonium salt. Significantly, when this important name reaction is employed the desired alkenes are constructed via a predictable manner, thus resultant particularly are useful in the total synthesis of natural products and synthetic complex organic compounds with definite geometric isomers, exhibiting diverse biological potencies. In this review we try to highlight the applications of the Wittig reaction as an efficient and attractive strategy in the total synthesis of macrolides from 2008 to 2020.
In this review we try to highlight the applications of the Wittig reaction in the total synthesis of natural products, classified as macrolide family, especially those showing biological potencies. We show the applications of the Wittig reaction as an efficient and attractive strategy in the total synthesis of macrolides from 2008 to 2020. |
| doi_str_mv | 10.1002/slct.202002192 |
| format | Article |
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In this review we try to highlight the applications of the Wittig reaction in the total synthesis of natural products, classified as macrolide family, especially those showing biological potencies. We show the applications of the Wittig reaction as an efficient and attractive strategy in the total synthesis of macrolides from 2008 to 2020.</description><identifier>ISSN: 2365-6549</identifier><identifier>EISSN: 2365-6549</identifier><identifier>DOI: 10.1002/slct.202002192</identifier><language>eng</language><subject>Macrolides ; Natural products ; Total synthesis ; Wittig reaction</subject><ispartof>ChemistrySelect (Weinheim), 2020-08, Vol.5 (31), p.9654-9690</ispartof><rights>2020 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3552-bbdaacd25e314af849d2d25570a04c32d291029a04380080b39612c295abf5903</citedby><cites>FETCH-LOGICAL-c3552-bbdaacd25e314af849d2d25570a04c32d291029a04380080b39612c295abf5903</cites><orcidid>0000-0003-2978-1157</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fslct.202002192$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fslct.202002192$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids></links><search><creatorcontrib>Heravi, Majid M.</creatorcontrib><creatorcontrib>Zadsirjan, Vahideh</creatorcontrib><creatorcontrib>Daraie, Mansoureh</creatorcontrib><creatorcontrib>Ghanbarian, Manizheh</creatorcontrib><title>Applications of Wittig Reaction in the Total Synthesis of Natural Macrolides</title><title>ChemistrySelect (Weinheim)</title><description>The Wittig reaction involves the synthesis of an alkene via the conversion of an aldehyde or ketone with the already generated ylide from a phosphonium salt. Significantly, when this important name reaction is employed the desired alkenes are constructed via a predictable manner, thus resultant particularly are useful in the total synthesis of natural products and synthetic complex organic compounds with definite geometric isomers, exhibiting diverse biological potencies. In this review we try to highlight the applications of the Wittig reaction as an efficient and attractive strategy in the total synthesis of macrolides from 2008 to 2020.
In this review we try to highlight the applications of the Wittig reaction in the total synthesis of natural products, classified as macrolide family, especially those showing biological potencies. We show the applications of the Wittig reaction as an efficient and attractive strategy in the total synthesis of macrolides from 2008 to 2020.</description><subject>Macrolides</subject><subject>Natural products</subject><subject>Total synthesis</subject><subject>Wittig reaction</subject><issn>2365-6549</issn><issn>2365-6549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFUE1LxDAUDKLgsu7Vc_5A60vSdJvjUvyCquBWPIY0TTUS29JEZP-96a6oN09vZph5A4PQOYGUANAL73RIKdCIiaBHaEFZzpOcZ-L4Dz5FK-_fAIDkRU75eoGqzTg6q1WwQ-_x0OFnG4J9wY9G6VnDtsfh1eB6CMrh7a6PxNu9816FjymKd0pPg7Ot8WfopFPOm9X3XaKnq8u6vEmqh-vbclMlmnFOk6ZpldIt5YaRTHVFJloaGV-DgkyziAUBKiJhBUABDRM5oZoKrpqOC2BLlB7-xmLvJ9PJcbLvatpJAnKeQ85zyJ85YkAcAp_Wmd0_brmtyvo3-wXls2Oj</recordid><startdate>20200821</startdate><enddate>20200821</enddate><creator>Heravi, Majid M.</creator><creator>Zadsirjan, Vahideh</creator><creator>Daraie, Mansoureh</creator><creator>Ghanbarian, Manizheh</creator><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-2978-1157</orcidid></search><sort><creationdate>20200821</creationdate><title>Applications of Wittig Reaction in the Total Synthesis of Natural Macrolides</title><author>Heravi, Majid M. ; Zadsirjan, Vahideh ; Daraie, Mansoureh ; Ghanbarian, Manizheh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3552-bbdaacd25e314af849d2d25570a04c32d291029a04380080b39612c295abf5903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Macrolides</topic><topic>Natural products</topic><topic>Total synthesis</topic><topic>Wittig reaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heravi, Majid M.</creatorcontrib><creatorcontrib>Zadsirjan, Vahideh</creatorcontrib><creatorcontrib>Daraie, Mansoureh</creatorcontrib><creatorcontrib>Ghanbarian, Manizheh</creatorcontrib><collection>CrossRef</collection><jtitle>ChemistrySelect (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heravi, Majid M.</au><au>Zadsirjan, Vahideh</au><au>Daraie, Mansoureh</au><au>Ghanbarian, Manizheh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Applications of Wittig Reaction in the Total Synthesis of Natural Macrolides</atitle><jtitle>ChemistrySelect (Weinheim)</jtitle><date>2020-08-21</date><risdate>2020</risdate><volume>5</volume><issue>31</issue><spage>9654</spage><epage>9690</epage><pages>9654-9690</pages><issn>2365-6549</issn><eissn>2365-6549</eissn><abstract>The Wittig reaction involves the synthesis of an alkene via the conversion of an aldehyde or ketone with the already generated ylide from a phosphonium salt. Significantly, when this important name reaction is employed the desired alkenes are constructed via a predictable manner, thus resultant particularly are useful in the total synthesis of natural products and synthetic complex organic compounds with definite geometric isomers, exhibiting diverse biological potencies. In this review we try to highlight the applications of the Wittig reaction as an efficient and attractive strategy in the total synthesis of macrolides from 2008 to 2020.
In this review we try to highlight the applications of the Wittig reaction in the total synthesis of natural products, classified as macrolide family, especially those showing biological potencies. We show the applications of the Wittig reaction as an efficient and attractive strategy in the total synthesis of macrolides from 2008 to 2020.</abstract><doi>10.1002/slct.202002192</doi><tpages>37</tpages><orcidid>https://orcid.org/0000-0003-2978-1157</orcidid></addata></record> |
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| subjects | Macrolides Natural products Total synthesis Wittig reaction |
| title | Applications of Wittig Reaction in the Total Synthesis of Natural Macrolides |
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