Insight on the Impact of the Reduction Step on the Site‐Directed Conjugation of an Anti‐HER2 Cysteine‐Engineered Antibody

Cysteine‐based conjugation is one of the main antibody conjugation strategies for generating both heterogeneous and homogeneous Antibody Drug Conjugates (ADCs), being the reduction of the antibody a crucial step in these processes. In this work we have analysed the reduction conditions for the site‐...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	ChemistrySelect (Weinheim) 2020-03, Vol.5 (11), p.3187-3190
Hauptverfasser:	Miret, Joan, Camps, Marc, Farràs, Mercè, Román, Ramón, Erb, Stéphane, Cianferani, Sarah, Casablancas, Antoni, Cairó, Jordi J.
Format:	Artikel
Sprache:	eng
Schlagworte:	antibody-drug conjugate Chemical Sciences Chemistry Chemistry, Multidisciplinary conjugation cysteine-engineered antibody Physical Sciences reduction Science & Technology Trastuzumab
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!