Determination of Ibuprofen in Tablets and Human Blood Samples: Effect of Clay in Minimizing Overvoltage of Ibuprofen Oxidation

In the current research, clay particles modified graphite electrode (Clay−CPE) was used for the electrocatalytic oxidation of ibuprofen (IBU). This clay was utilized to reduce the distortions of ibuprofen oxidation peak shape and for a better signal to noise ratio. The surface characterization of the clay and their activity toward IBU oxidation were studied by electrochemical methods in particular: cyclic voltammetry, Tafel plots and electrochemical impedance spectroscopy. The number of the electrons, rate constant and kinetic parameters related to ibuprofen oxidation were calculated. The ibuprofen peak gets more symmetrical in the presence of clay giving a detection limit (LOD) of 8.35×10−7 mol L−1 (3Sb/M) using differential pulse voltammetry. The main practical applicability of the modified electrode was explored by determining ibuprofen in tablets and human blood samples. This work reports the electrocatalytic oxidation of ibuprofen using clay particles modified graphite electrode (Clay−CPE). This clay exhibited remarkable electrocatalytic activity for ibuprofen oxidation and an excellent performance for the determination of ibuprofen in human blood and pharmaceutical tablets.