Design, Synthesis and Docking Calculations of Prenylated Chalcones as Selective Monoamine Oxidase B Inhibitors with Antioxidant Activity

Different natural and synthetic chalcones have exhibited selective inhibition on monoamine oxidase B (MAO−B) activity, demonstrating potential interest for the treatment of neurodegenerative diseases. Herein we report the synthesis of seven new prenylated chalcones (7a‐g) obtained from the natural c...

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Veröffentlicht in:	ChemistrySelect (Weinheim) 2019-07, Vol.4 (26), p.7698-7703
Hauptverfasser:	Mellado, Marco, Salas, Cristian O., Uriarte, Eugenio, Viña, Dolores, Jara‐Gutiérrez, Carlos, Matos, Maria J., Cuellar, Mauricio
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidant activity Claisen-Schmidt reaction Molecular docking Monoamine oxidase B inhibitors Prenyl-chalcones
Online-Zugang:	Volltext
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