Antichagasic profile of a Series of Mannich Base‐Type Derivatives: Design, Synthesis, in vitro Evaluation, and Computational Studies Involving Iron Superoxide Dismutase

Chagas disease is a silent disease that continues to endanger millions of people and, due to its insufficient current chemotherapy, urgently requires the development of more effective drugs. With this objective, twenty‐six Mannich base derivatives were synthesized, and their in vitro activity was ev...

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Veröffentlicht in:	ChemistrySelect (Weinheim) 2019-07, Vol.4 (27), p.8112-8121
Hauptverfasser:	Paucar, Rocío, Martín‐Escolano, Rubén, Moreno‐Viguri, Elsa, Cirauqui, Nuria, Marín, Clotilde, Sánchez‐Moreno, Manuel, Pérez‐Silanes, Silvia
Format:	Artikel
Sprache:	eng
Schlagworte:	Chagas disease Drug discovery Mannich bases Superoxide dismutase Trypanosoma cruzi
Online-Zugang:	Volltext
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