Rapid, Simple and Efficient Microwave‐Assisted Alkylation of 6‐Acetyl‐2 H ‐Benzo[e][1, 3] Oxazine‐2, 4(3 H )‐Dione

A simple, efficient and eco‐friendly method has been developed for the synthesis of biologically active alkyl derivatives of 6‐acetyl‐2 H ‐benzo[ e ][1,3]oxazine‐2,4(3 H )‐dione by using microwave irradiations. The N‐alkylation of 6‐acetyl‐2 H ‐benzo[ e ][1,3]oxazine‐2,4(3 H )‐dione with substituted alkyl derivatives under microwave radiations in presence of Tetra‐n‐butyl ammonium bromide as a phase transfer catalyst to give the desired products. Comparison between conventional and microwave‐assisted synthesis revealed that it reduced the reaction time, improve the yield and purity of 6‐acetyl‐3‐(substituted alkyl)‐2 H ‐benzo[ e ][1,3]oxazine‐2,4(3 H )‐diones analog molecules. All the final compounds were characterized by FT‐IR, 1 HNMR, 13 CNMR, HRMS and Mass spectroscopic analysis, also succeeded to develop and analyze the single crystal XRD of compound 4 f. The antimicrobial evaluation studies show moderate activities against used microbes.