Green Synthesis of 1,4‐Dihydropyridine Derivative in Water

A simple and environmentally clean synthesis of 4‐methoxycarbonylmethyl‐1,4‐dihydropyridine‐3,5‐dicarboxylic acid dimethyl ester was achieved by heating methyl propiolate with an amine salt in water. Excess amine salt accelerated the reaction in the case of aliphatic amines, while stoichiometric amo...

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Veröffentlicht in:	ChemistrySelect (Weinheim) 2018-03, Vol.3 (11), p.3003-3005
Hauptverfasser:	Isomura, Shigeki, Horigome, Ami, Kubo, Kotaro, Yoshizawa, Yukari, Okuno, Yoshinori, Okayasu, Misaki, Azumaya, Isao, Sato, Yasuo
Format:	Artikel
Sprache:	eng
Schlagworte:	1,4-dihydropyridine amine salt methyl propiolate Michael addition water
Online-Zugang:	Volltext
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