Concentration-dependent stimulation by tissue inhibitor of metalloproteinases(TIMP)-2 of two signaling pathways in human osteosarcoma (MG-63) Cells

We reported previously that tyrosine kinase (TYK) and mitogen‐activated protein kinase (MAPK) play a role in TIMP‐dependent growth signaling. Here we demonstrate that the activation of MAPK stimulated by TIMP‐2 was sharply inhibited in MG‐63 cells by PP1, a selective inhibitor of Src‐family tyrosine...

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Veröffentlicht in:	Signal transduction 2006-08, Vol.6 (4), p.280-286
Hauptverfasser:	Wang, Ting, Kondo, Chihiro, Yamashita, Kyoko, Oguchi, Masayo, Iwata, Kazushi, Noguchi, Toshihide, Hayakawa, Taro
Format:	Artikel
Sprache:	eng
Schlagworte:	cAMP/PKA pathway Negative crosstalk Ras-independent TIMP-2 TYK/MAPK pathway
Online-Zugang:	Volltext
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