Development and validation of an isotope-dilution electrospray ionization tandem mass spectrometry method with an on-line sample clean-up device for the quantitative analysis of the benzene exposure biomarker S-phenylmercapturic acid in human urine

An isotope‐dilution electrospray ionization tandem mass spectrometry (ESI‐MS/MS) method with an on‐line sample clean‐up device, for the quantitative analysis of human urine for the benzene exposure biomarker S‐phenylmercapturic acid (SPMA), was developed and validated. The sample clean‐up system was...

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Veröffentlicht in:	Rapid communications in mass spectrometry 2004-01, Vol.18 (12), p.1310-1316
Hauptverfasser:	Lin, Lung-Cheng, Tyan, Yu-Chang, Shih, Tung-Sheng, Chang, Yu-Chen, Liao, Pao-Chi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - analogs & derivatives Acetylcysteine - urine Adult Benzene - metabolism Biomarkers - urine Environmental Exposure Humans Infant, Newborn Online Systems Reproducibility of Results Sensitivity and Specificity Spectrometry, Mass, Electrospray Ionization - methods Urinalysis
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