Chlorotrityl Chloride (CTC) Resin as a Reusable Carboxyl Protecting Group

Chlorotrityl Chloride (CTC) Resin as a Reusable Carboxyl Protecting Group

Chlorotrityl Chloride (CTC) resin is one of the most useful resins for the solid‐phase synthesis of C‐terminal acid peptides. CTC resin can be used for the preparation of both protected and unprotected peptides. Herein, the use of CTC resin as a reusable mild protecting group of carboxylic acids is...

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Veröffentlicht in:QSAR & combinatorial science 2007-10, Vol.26 (10), p.1027-1035
Hauptverfasser: García-Martín, Fayna, Bayó-Puxan, Núria, Cruz, Luis J., Bohling, James C., Albericio, Fernando
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Sprache:eng
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Combinatorial chemistry
Microwave energy
Orthogonal protecting groups
Resins
Solid supports
Solid-phase peptide synthesis
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container_end_page 1035
container_issue 10
container_start_page 1027
container_title QSAR & combinatorial science
container_volume 26
creator García-Martín, Fayna
Bayó-Puxan, Núria
Cruz, Luis J.
Bohling, James C.
Albericio, Fernando
description Chlorotrityl Chloride (CTC) resin is one of the most useful resins for the solid‐phase synthesis of C‐terminal acid peptides. CTC resin can be used for the preparation of both protected and unprotected peptides. Herein, the use of CTC resin as a reusable mild protecting group of carboxylic acids is introduced. Temporary protection of carboxylic acids in solution is not a straightforward process, but the use of CTC resin is shown to be an alternative to classic solution procedures. Regeneration of the CTC resin after cleavage of the target compounds is feasible, which allows the reuse of the resin. Applications described herein encompass the preparation of noncommercial amino acids as well as complex dipeptides.
doi_str_mv 10.1002/qsar.200720015
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source Wiley Online Library Journals Frontfile Complete
subjects Combinatorial chemistry
Microwave energy
Orthogonal protecting groups
Resins
Solid supports
Solid-phase peptide synthesis
title Chlorotrityl Chloride (CTC) Resin as a Reusable Carboxyl Protecting Group
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