Identification of novel cannabinoid receptor ligands via evolutionary de novo design and rapid parallel synthesis

A rapid entry to novel and patentable cannabinoid receptor (CB‐1) ligands has been identified using computer‐based de novo design in combination with parallel synthesis. Small targeted compound arrays were readily prepared from the designs yielding active hit rates of 6% and 10%, respectively. This...

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Veröffentlicht in:	QSAR & combinatorial science 2004-07, Vol.23 (6), p.426-430
Hauptverfasser:	Rogers-Evans, Mark, Alanine, Alexander I., Bleicher, Konrad H., Kube, Dagmar, Schneider, Gisbert
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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