Effects of tanshinone I isolated from Salvia miltiorrhiza Bunge on arachidonic acid metabolism and in vivo inflammatory responses

Arachidonic acid (AA) mainly released from the cell membrane by phospholipase A2 (PLA2) is converted to eicosanoids by the action of cyclooxygenase (COX) and lipoxygenase (LO). In order to find the specific inhibitors of AA metabolism especially PLA2 and COX‐2, 300 plant extracts were evaluated for...

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Veröffentlicht in:	Phytotherapy research 2002-11, Vol.16 (7), p.616-620
Hauptverfasser:	Kim, Sung Young, Moon, Tae Cheol, Chang, Hyeun Wook, Son, Kun Ho, Kang, Sam Sik, Kim, Hyun Pyo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use antiinflammation Arachidonic Acid - pharmacokinetics Arthritis, Experimental - chemically induced Arthritis, Experimental - drug therapy Blotting, Western Carrageenan Cyclooxygenase 2 Diterpenes, Abietane Dose-Response Relationship, Drug Edema - chemically induced Edema - drug therapy Humans Inhibitory Concentration 50 Isoenzymes - biosynthesis Isoenzymes - drug effects Male Mast Cells - drug effects Membrane Proteins Mice Phenanthrenes - administration & dosage Phenanthrenes - pharmacology Phenanthrenes - therapeutic use phospholipase A2 Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Prostaglandin D2 - biosynthesis Prostaglandin D2 - metabolism Prostaglandin-Endoperoxide Synthases - biosynthesis Prostaglandin-Endoperoxide Synthases - drug effects Rabbits Rats Rats, Sprague-Dawley RAW 264.7 Salvia miltiorrhiza Salvia miltiorrhiza Bunge tanshinone I
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