In vitro anti-hepatoma activity of fifteen natural medicines from Canada
Fifteen crude drugs, Stellaria media Cyrill. (Caryophyllaceae), Calendula officinalis L. (Compositae), Achillea millefolium L. (Compositae), Verbascum thapsus L. (Scrophulariaceae), Plantago major L. (Plantaginaceae), Borago officinalis L. (Boraginaceae), Satureja hortensis L. (Labiatae), Coptis gro...
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| Veröffentlicht in: | Phytotherapy research 2002-08, Vol.16 (5), p.440-444 |
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| creator | Lin, Liang-Tzung Liu, Li-Teh Chiang, Lien-Chai Lin, Chun-Ching |
| description | Fifteen crude drugs, Stellaria media Cyrill. (Caryophyllaceae), Calendula officinalis L. (Compositae), Achillea millefolium L. (Compositae), Verbascum thapsus L. (Scrophulariaceae), Plantago major L. (Plantaginaceae), Borago officinalis L. (Boraginaceae), Satureja hortensis L. (Labiatae), Coptis groenlandica Salisb. (Ranunculaceae), Cassia angustifolia Vahl. (Leguminosae), Origanum majorana L. (Labiatae), Centella asiatica L. (Umbelliferae), Caulophyllum thalictroides Mich. (Berberidaceae), Picea rubens Sargent. (Pinaceae), Rhamnus purshiana D.C. (Rhamnaceae) and Hibiscus sabdariffa L. (Malvaceae), which have been used as folk medicine in Canada, were evaluated for their anti‐hepatoma activity on five human liver‐cancer cell lines, i.e. HepG2/C3A, SK‐HEP‐1, HA22T/VGH, Hep3B and PLC/PRF/5. The samples were examined by in vitro evaluation for their cytotoxicity. The results showed that the effects of crude drugs on hepatitis B virus genome‐containing cell lines were different from those against non hepatitis B virus genome‐containing cell lines. C. groenlandica was observed to be the most effective against the growth of all five cell lines and its chemotherapeutic values will be of interest for further studies. Copyright © 2002 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.937 |
| format | Article |
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(Caryophyllaceae), Calendula officinalis L. (Compositae), Achillea millefolium L. (Compositae), Verbascum thapsus L. (Scrophulariaceae), Plantago major L. (Plantaginaceae), Borago officinalis L. (Boraginaceae), Satureja hortensis L. (Labiatae), Coptis groenlandica Salisb. (Ranunculaceae), Cassia angustifolia Vahl. (Leguminosae), Origanum majorana L. (Labiatae), Centella asiatica L. (Umbelliferae), Caulophyllum thalictroides Mich. (Berberidaceae), Picea rubens Sargent. (Pinaceae), Rhamnus purshiana D.C. (Rhamnaceae) and Hibiscus sabdariffa L. (Malvaceae), which have been used as folk medicine in Canada, were evaluated for their anti‐hepatoma activity on five human liver‐cancer cell lines, i.e. HepG2/C3A, SK‐HEP‐1, HA22T/VGH, Hep3B and PLC/PRF/5. The samples were examined by in vitro evaluation for their cytotoxicity. The results showed that the effects of crude drugs on hepatitis B virus genome‐containing cell lines were different from those against non hepatitis B virus genome‐containing cell lines. C. groenlandica was observed to be the most effective against the growth of all five cell lines and its chemotherapeutic values will be of interest for further studies. Copyright © 2002 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.937</identifier><identifier>PMID: 12203264</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>anti-hepatoma activity ; Antineoplastic Agents, Phytogenic - adverse effects ; Antineoplastic Agents, Phytogenic - pharmacology ; Antineoplastic Agents, Phytogenic - therapeutic use ; Biological and medical sciences ; Canada ; Cell Division - drug effects ; crude drugs ; Drug Screening Assays, Antitumor ; General pharmacology ; HBV ; Humans ; Inhibitory Concentration 50 ; Liver Neoplasms - drug therapy ; Liver Neoplasms - pathology ; Medical sciences ; natural medicines ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy ; Plant Extracts - adverse effects ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plants, Medicinal - chemistry ; Tumor Cells, Cultured ; tumour</subject><ispartof>Phytotherapy research, 2002-08, Vol.16 (5), p.440-444</ispartof><rights>Copyright © 2002 John Wiley & Sons, Ltd.</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4477-9e1e5bbfb18e6cb710236ccad457ed74013e2f9627420ccb8c1f9310aa366b973</citedby><cites>FETCH-LOGICAL-c4477-9e1e5bbfb18e6cb710236ccad457ed74013e2f9627420ccb8c1f9310aa366b973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.937$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.937$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13863924$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12203264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Liang-Tzung</creatorcontrib><creatorcontrib>Liu, Li-Teh</creatorcontrib><creatorcontrib>Chiang, Lien-Chai</creatorcontrib><creatorcontrib>Lin, Chun-Ching</creatorcontrib><title>In vitro anti-hepatoma activity of fifteen natural medicines from Canada</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>Fifteen crude drugs, Stellaria media Cyrill. (Caryophyllaceae), Calendula officinalis L. (Compositae), Achillea millefolium L. (Compositae), Verbascum thapsus L. (Scrophulariaceae), Plantago major L. (Plantaginaceae), Borago officinalis L. (Boraginaceae), Satureja hortensis L. (Labiatae), Coptis groenlandica Salisb. (Ranunculaceae), Cassia angustifolia Vahl. (Leguminosae), Origanum majorana L. (Labiatae), Centella asiatica L. (Umbelliferae), Caulophyllum thalictroides Mich. (Berberidaceae), Picea rubens Sargent. (Pinaceae), Rhamnus purshiana D.C. (Rhamnaceae) and Hibiscus sabdariffa L. (Malvaceae), which have been used as folk medicine in Canada, were evaluated for their anti‐hepatoma activity on five human liver‐cancer cell lines, i.e. HepG2/C3A, SK‐HEP‐1, HA22T/VGH, Hep3B and PLC/PRF/5. The samples were examined by in vitro evaluation for their cytotoxicity. The results showed that the effects of crude drugs on hepatitis B virus genome‐containing cell lines were different from those against non hepatitis B virus genome‐containing cell lines. C. groenlandica was observed to be the most effective against the growth of all five cell lines and its chemotherapeutic values will be of interest for further studies. Copyright © 2002 John Wiley & Sons, Ltd.</description><subject>anti-hepatoma activity</subject><subject>Antineoplastic Agents, Phytogenic - adverse effects</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Antineoplastic Agents, Phytogenic - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Canada</subject><subject>Cell Division - drug effects</subject><subject>crude drugs</subject><subject>Drug Screening Assays, Antitumor</subject><subject>General pharmacology</subject><subject>HBV</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Liver Neoplasms - pathology</subject><subject>Medical sciences</subject><subject>natural medicines</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Extracts - adverse effects</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plants, Medicinal - chemistry</subject><subject>Tumor Cells, Cultured</subject><subject>tumour</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10FtPwjAUB_DGaATR-A1MX4wPZtjLtq6PhihgiALBy1tzVtpYhY20Q-XbOzIiTz6d5OSXc_kjdE5JlxLCblaV70ouDlCbEikjmgh-iNpEJjSKafbWQichfBBCJCPxMWpRxghnadxGg2GBv1zlSwxF5aJ3s4KqXAIGXbm6v8GlxdbZypgCF1CtPSzw0syddoUJ2PpyiXtQwBxO0ZGFRTBnu9pBz_d3s94gGj31h73bUaTjWIhIGmqSPLc5zUyqc0EJ46nWMI8TYeYiJpQbZmXKRMyI1nmmqZWcEgCeprkUvIOumrnalyF4Y9XKuyX4jaJEbbNQdRaqzqKWF41crfP65L3bPV-Dyx2AoGFhPRTahb3jWcol27rrxn27hdn8t0-NZ9NmbdRoFyrz86fBf6pUcJGo18e-mkwnWS95eVBj_gu1SYP-</recordid><startdate>200208</startdate><enddate>200208</enddate><creator>Lin, Liang-Tzung</creator><creator>Liu, Li-Teh</creator><creator>Chiang, Lien-Chai</creator><creator>Lin, Chun-Ching</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200208</creationdate><title>In vitro anti-hepatoma activity of fifteen natural medicines from Canada</title><author>Lin, Liang-Tzung ; Liu, Li-Teh ; Chiang, Lien-Chai ; Lin, Chun-Ching</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4477-9e1e5bbfb18e6cb710236ccad457ed74013e2f9627420ccb8c1f9310aa366b973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>anti-hepatoma activity</topic><topic>Antineoplastic Agents, Phytogenic - adverse effects</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Antineoplastic Agents, Phytogenic - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Canada</topic><topic>Cell Division - drug effects</topic><topic>crude drugs</topic><topic>Drug Screening Assays, Antitumor</topic><topic>General pharmacology</topic><topic>HBV</topic><topic>Humans</topic><topic>Inhibitory Concentration 50</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Liver Neoplasms - pathology</topic><topic>Medical sciences</topic><topic>natural medicines</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Plant Extracts - adverse effects</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plants, Medicinal - chemistry</topic><topic>Tumor Cells, Cultured</topic><topic>tumour</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Liang-Tzung</creatorcontrib><creatorcontrib>Liu, Li-Teh</creatorcontrib><creatorcontrib>Chiang, Lien-Chai</creatorcontrib><creatorcontrib>Lin, Chun-Ching</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Liang-Tzung</au><au>Liu, Li-Teh</au><au>Chiang, Lien-Chai</au><au>Lin, Chun-Ching</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro anti-hepatoma activity of fifteen natural medicines from Canada</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2002-08</date><risdate>2002</risdate><volume>16</volume><issue>5</issue><spage>440</spage><epage>444</epage><pages>440-444</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>Fifteen crude drugs, Stellaria media Cyrill. (Caryophyllaceae), Calendula officinalis L. (Compositae), Achillea millefolium L. (Compositae), Verbascum thapsus L. (Scrophulariaceae), Plantago major L. (Plantaginaceae), Borago officinalis L. (Boraginaceae), Satureja hortensis L. (Labiatae), Coptis groenlandica Salisb. (Ranunculaceae), Cassia angustifolia Vahl. (Leguminosae), Origanum majorana L. (Labiatae), Centella asiatica L. (Umbelliferae), Caulophyllum thalictroides Mich. (Berberidaceae), Picea rubens Sargent. (Pinaceae), Rhamnus purshiana D.C. (Rhamnaceae) and Hibiscus sabdariffa L. (Malvaceae), which have been used as folk medicine in Canada, were evaluated for their anti‐hepatoma activity on five human liver‐cancer cell lines, i.e. HepG2/C3A, SK‐HEP‐1, HA22T/VGH, Hep3B and PLC/PRF/5. The samples were examined by in vitro evaluation for their cytotoxicity. The results showed that the effects of crude drugs on hepatitis B virus genome‐containing cell lines were different from those against non hepatitis B virus genome‐containing cell lines. C. groenlandica was observed to be the most effective against the growth of all five cell lines and its chemotherapeutic values will be of interest for further studies. Copyright © 2002 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>12203264</pmid><doi>10.1002/ptr.937</doi><tpages>5</tpages></addata></record> |
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| ispartof | Phytotherapy research, 2002-08, Vol.16 (5), p.440-444 |
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| subjects | anti-hepatoma activity Antineoplastic Agents, Phytogenic - adverse effects Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Biological and medical sciences Canada Cell Division - drug effects crude drugs Drug Screening Assays, Antitumor General pharmacology HBV Humans Inhibitory Concentration 50 Liver Neoplasms - drug therapy Liver Neoplasms - pathology Medical sciences natural medicines Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - adverse effects Plant Extracts - pharmacology Plant Extracts - therapeutic use Plants, Medicinal - chemistry Tumor Cells, Cultured tumour |
| title | In vitro anti-hepatoma activity of fifteen natural medicines from Canada |
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