Preventative effects of the flowers of Inula britannica on autoimmune diabetes in C57BL/KsJ mice induced by multiple low doses of streptozotocin
We have reported that an aqueous extract from the flowers of Inula britannica L. subsp. japonica Kitam. (IB) prevented immunologically induced experimental hepatitis in mice and suggested that the antihepatitic effect of IB is due to inhibition of IFN‐γ production. We then investigated the effects o...
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| Veröffentlicht in: | Phytotherapy research 2002-06, Vol.16 (4), p.377-382 |
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| creator | Kobayashi, Takao Song, Qing-Hua Hong, Tie Kitamura, Hajime Cyong, Jong-Chol |
| description | We have reported that an aqueous extract from the flowers of Inula britannica L. subsp. japonica Kitam. (IB) prevented immunologically induced experimental hepatitis in mice and suggested that the antihepatitic effect of IB is due to inhibition of IFN‐γ production. We then investigated the effects of IB on diabetes in mice induced by multiple low doses of streptozotocin (MLDSTZ), which is a mouse model for IFN‐γ‐dependent autoimmune diabetes. C57BL/KsJ mice (male, 7 weeks) were provided with IB extract (500 mg/ kg/ day) in drinking water ad libitum, starting 7 days before the first STZ injection. Autoimmune diabetes was induced by MLDSTZ (40 mg/kg/day for 5 daily doses, i.p.). The IB treatment significantly suppressed the increase of blood glucose levels. Histological analysis of the pancreas showed that the degree of insulitis and destruction of β‐cells were reduced by IB treatment. The IFN‐γ production from stimulated splenic T lymphocytes was inhibited by the IB treatment. Moreover, the proportion of IFN‐γ‐producing cells in the CD4+ population, which was increased by MLDSTZ, was significantly decreased by the IB treatment. These results suggest that IB has a preventative effect on autoimmune diabetes by regulating cytokine production. Copyright © 2002 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.868 |
| format | Article |
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(IB) prevented immunologically induced experimental hepatitis in mice and suggested that the antihepatitic effect of IB is due to inhibition of IFN‐γ production. We then investigated the effects of IB on diabetes in mice induced by multiple low doses of streptozotocin (MLDSTZ), which is a mouse model for IFN‐γ‐dependent autoimmune diabetes. C57BL/KsJ mice (male, 7 weeks) were provided with IB extract (500 mg/ kg/ day) in drinking water ad libitum, starting 7 days before the first STZ injection. Autoimmune diabetes was induced by MLDSTZ (40 mg/kg/day for 5 daily doses, i.p.). The IB treatment significantly suppressed the increase of blood glucose levels. Histological analysis of the pancreas showed that the degree of insulitis and destruction of β‐cells were reduced by IB treatment. The IFN‐γ production from stimulated splenic T lymphocytes was inhibited by the IB treatment. Moreover, the proportion of IFN‐γ‐producing cells in the CD4+ population, which was increased by MLDSTZ, was significantly decreased by the IB treatment. These results suggest that IB has a preventative effect on autoimmune diabetes by regulating cytokine production. Copyright © 2002 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.868</identifier><identifier>PMID: 12112297</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; autoimmune diabetes ; Biological and medical sciences ; Blood Glucose - drug effects ; Body Weight - drug effects ; cytokines ; Diabetes Mellitus, Experimental - chemically induced ; Diabetes Mellitus, Experimental - immunology ; Diabetes Mellitus, Experimental - pathology ; Diabetes Mellitus, Experimental - prevention & control ; Diabetes Mellitus, Type 1 - chemically induced ; Diabetes Mellitus, Type 1 - immunology ; Diabetes Mellitus, Type 1 - pathology ; Diabetes Mellitus, Type 1 - prevention & control ; Disease Models, Animal ; Drug Administration Schedule ; General pharmacology ; Hypoglycemic Agents - pharmacology ; Interferon-gamma - biosynthesis ; Interleukin-4 - biosynthesis ; Inula - chemistry ; Inula britannica ; Islets of Langerhans - drug effects ; Islets of Langerhans - pathology ; Male ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Structures - chemistry ; Streptozocin - administration & dosage ; Streptozocin - pharmacology ; streptozotocin ; T lymphocyte ; traditional herbal medicine</subject><ispartof>Phytotherapy research, 2002-06, Vol.16 (4), p.377-382</ispartof><rights>Copyright © 2002 John Wiley & Sons, Ltd.</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4478-f4a141b4cc2fed944bb04876c6b777f15ec63b3e71b091ec8fef560bcd959e613</citedby><cites>FETCH-LOGICAL-c4478-f4a141b4cc2fed944bb04876c6b777f15ec63b3e71b091ec8fef560bcd959e613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.868$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.868$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13728881$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12112297$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kobayashi, Takao</creatorcontrib><creatorcontrib>Song, Qing-Hua</creatorcontrib><creatorcontrib>Hong, Tie</creatorcontrib><creatorcontrib>Kitamura, Hajime</creatorcontrib><creatorcontrib>Cyong, Jong-Chol</creatorcontrib><title>Preventative effects of the flowers of Inula britannica on autoimmune diabetes in C57BL/KsJ mice induced by multiple low doses of streptozotocin</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>We have reported that an aqueous extract from the flowers of Inula britannica L. subsp. japonica Kitam. (IB) prevented immunologically induced experimental hepatitis in mice and suggested that the antihepatitic effect of IB is due to inhibition of IFN‐γ production. We then investigated the effects of IB on diabetes in mice induced by multiple low doses of streptozotocin (MLDSTZ), which is a mouse model for IFN‐γ‐dependent autoimmune diabetes. C57BL/KsJ mice (male, 7 weeks) were provided with IB extract (500 mg/ kg/ day) in drinking water ad libitum, starting 7 days before the first STZ injection. Autoimmune diabetes was induced by MLDSTZ (40 mg/kg/day for 5 daily doses, i.p.). The IB treatment significantly suppressed the increase of blood glucose levels. Histological analysis of the pancreas showed that the degree of insulitis and destruction of β‐cells were reduced by IB treatment. The IFN‐γ production from stimulated splenic T lymphocytes was inhibited by the IB treatment. Moreover, the proportion of IFN‐γ‐producing cells in the CD4+ population, which was increased by MLDSTZ, was significantly decreased by the IB treatment. These results suggest that IB has a preventative effect on autoimmune diabetes by regulating cytokine production. Copyright © 2002 John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>autoimmune diabetes</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - drug effects</subject><subject>Body Weight - drug effects</subject><subject>cytokines</subject><subject>Diabetes Mellitus, Experimental - chemically induced</subject><subject>Diabetes Mellitus, Experimental - immunology</subject><subject>Diabetes Mellitus, Experimental - pathology</subject><subject>Diabetes Mellitus, Experimental - prevention & control</subject><subject>Diabetes Mellitus, Type 1 - chemically induced</subject><subject>Diabetes Mellitus, Type 1 - immunology</subject><subject>Diabetes Mellitus, Type 1 - pathology</subject><subject>Diabetes Mellitus, Type 1 - prevention & control</subject><subject>Disease Models, Animal</subject><subject>Drug Administration Schedule</subject><subject>General pharmacology</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interleukin-4 - biosynthesis</subject><subject>Inula - chemistry</subject><subject>Inula britannica</subject><subject>Islets of Langerhans - drug effects</subject><subject>Islets of Langerhans - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Structures - chemistry</subject><subject>Streptozocin - administration & dosage</subject><subject>Streptozocin - pharmacology</subject><subject>streptozotocin</subject><subject>T lymphocyte</subject><subject>traditional herbal medicine</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MFu1DAUBVALgehQEH-AvEEsUFo7ceJ4SUdQCiMYVQVmZ9nOszAkdmQ7LcNX8MmkzYiuWFnPOrpXugg9p-SEElKejjmetE37AK0oEaKgNa8eohURNS0YbXdH6ElKPwghoiTsMTqiJaVlKfgK_dlGuAafVXbXgMFaMDnhYHH-Dtj24Qbi3Xnhp15hHV1W3jujcPBYTTm4YZg84M4pDRkSdh6va362Of2YPuDBGZh_uslAh_UeD1Of3dgDnnNxFxLcRaccYczhd8jBOP8UPbKqT_Ds8B6jL-_eXq3fF5vP5xfrN5vCMMbbwjJFGdXMmNJCJxjTmrCWN6bRnHNLazBNpSvgVBNBwbQWbN0QbTpRC2hodYxeLbkmhpQiWDlGN6i4l5TI203lvKmcN53li0WOkx6gu3eHEWfw8gBUMqq3UXnj0r2reNm27W3l68XduB72_-uT26vLpbZYtEsZfv3TKv6UDa94Lb99Opf0crf9ut3NR_UXaB6fNA</recordid><startdate>200206</startdate><enddate>200206</enddate><creator>Kobayashi, Takao</creator><creator>Song, Qing-Hua</creator><creator>Hong, Tie</creator><creator>Kitamura, Hajime</creator><creator>Cyong, Jong-Chol</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200206</creationdate><title>Preventative effects of the flowers of Inula britannica on autoimmune diabetes in C57BL/KsJ mice induced by multiple low doses of streptozotocin</title><author>Kobayashi, Takao ; Song, Qing-Hua ; Hong, Tie ; Kitamura, Hajime ; Cyong, Jong-Chol</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4478-f4a141b4cc2fed944bb04876c6b777f15ec63b3e71b091ec8fef560bcd959e613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>autoimmune diabetes</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - drug effects</topic><topic>Body Weight - drug effects</topic><topic>cytokines</topic><topic>Diabetes Mellitus, Experimental - chemically induced</topic><topic>Diabetes Mellitus, Experimental - immunology</topic><topic>Diabetes Mellitus, Experimental - pathology</topic><topic>Diabetes Mellitus, Experimental - prevention & control</topic><topic>Diabetes Mellitus, Type 1 - chemically induced</topic><topic>Diabetes Mellitus, Type 1 - immunology</topic><topic>Diabetes Mellitus, Type 1 - pathology</topic><topic>Diabetes Mellitus, Type 1 - prevention & control</topic><topic>Disease Models, Animal</topic><topic>Drug Administration Schedule</topic><topic>General pharmacology</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interleukin-4 - biosynthesis</topic><topic>Inula - chemistry</topic><topic>Inula britannica</topic><topic>Islets of Langerhans - drug effects</topic><topic>Islets of Langerhans - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Structures - chemistry</topic><topic>Streptozocin - administration & dosage</topic><topic>Streptozocin - pharmacology</topic><topic>streptozotocin</topic><topic>T lymphocyte</topic><topic>traditional herbal medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kobayashi, Takao</creatorcontrib><creatorcontrib>Song, Qing-Hua</creatorcontrib><creatorcontrib>Hong, Tie</creatorcontrib><creatorcontrib>Kitamura, Hajime</creatorcontrib><creatorcontrib>Cyong, Jong-Chol</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kobayashi, Takao</au><au>Song, Qing-Hua</au><au>Hong, Tie</au><au>Kitamura, Hajime</au><au>Cyong, Jong-Chol</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preventative effects of the flowers of Inula britannica on autoimmune diabetes in C57BL/KsJ mice induced by multiple low doses of streptozotocin</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2002-06</date><risdate>2002</risdate><volume>16</volume><issue>4</issue><spage>377</spage><epage>382</epage><pages>377-382</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>We have reported that an aqueous extract from the flowers of Inula britannica L. subsp. japonica Kitam. (IB) prevented immunologically induced experimental hepatitis in mice and suggested that the antihepatitic effect of IB is due to inhibition of IFN‐γ production. We then investigated the effects of IB on diabetes in mice induced by multiple low doses of streptozotocin (MLDSTZ), which is a mouse model for IFN‐γ‐dependent autoimmune diabetes. C57BL/KsJ mice (male, 7 weeks) were provided with IB extract (500 mg/ kg/ day) in drinking water ad libitum, starting 7 days before the first STZ injection. Autoimmune diabetes was induced by MLDSTZ (40 mg/kg/day for 5 daily doses, i.p.). The IB treatment significantly suppressed the increase of blood glucose levels. Histological analysis of the pancreas showed that the degree of insulitis and destruction of β‐cells were reduced by IB treatment. The IFN‐γ production from stimulated splenic T lymphocytes was inhibited by the IB treatment. Moreover, the proportion of IFN‐γ‐producing cells in the CD4+ population, which was increased by MLDSTZ, was significantly decreased by the IB treatment. These results suggest that IB has a preventative effect on autoimmune diabetes by regulating cytokine production. Copyright © 2002 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>12112297</pmid><doi>10.1002/ptr.868</doi><tpages>6</tpages></addata></record> |
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| ispartof | Phytotherapy research, 2002-06, Vol.16 (4), p.377-382 |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Animals autoimmune diabetes Biological and medical sciences Blood Glucose - drug effects Body Weight - drug effects cytokines Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - immunology Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - prevention & control Diabetes Mellitus, Type 1 - chemically induced Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - pathology Diabetes Mellitus, Type 1 - prevention & control Disease Models, Animal Drug Administration Schedule General pharmacology Hypoglycemic Agents - pharmacology Interferon-gamma - biosynthesis Interleukin-4 - biosynthesis Inula - chemistry Inula britannica Islets of Langerhans - drug effects Islets of Langerhans - pathology Male Medical sciences Mice Mice, Inbred C57BL Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - chemistry Plant Extracts - pharmacology Plant Structures - chemistry Streptozocin - administration & dosage Streptozocin - pharmacology streptozotocin T lymphocyte traditional herbal medicine |
| title | Preventative effects of the flowers of Inula britannica on autoimmune diabetes in C57BL/KsJ mice induced by multiple low doses of streptozotocin |
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