Protective Effect of Lycium barbarum Polysaccharides Against Doxorubicin‐induced Testicular Toxicity in Rats
The present study aimed to investigate whether Lycium barbarum polysaccharides (LBP) would protect against doxorubicin (DOX)‐induced testicular toxicity. Male Sprague‐Dawley rats were treated with distilled water (4 mL/kg) or LBP (200 mg/kg, p.o.) daily for 10 days and followed by saline (0.9 %, 10 ...
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| Veröffentlicht in: | Phytotherapy research 2012-05, Vol.26 (5), p.716-721 |
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| creator | Xin, Yan‐Fei You, Zhen‐Qiang Gao, Hai‐yan Zhou, Guo‐Liang Chen, Yun‐Xiang Yu, Jian Xuan, Yao‐Xian |
| description | The present study aimed to investigate whether Lycium barbarum polysaccharides (LBP) would protect against doxorubicin (DOX)‐induced testicular toxicity. Male Sprague‐Dawley rats were treated with distilled water (4 mL/kg) or LBP (200 mg/kg, p.o.) daily for 10 days and followed by saline (0.9 %, 10 mL/kg) or DOX (10 mg/kg) intravenous injection at day 7. Pretreatment with LBP ameliorated DOX‐induced reduction in the testicular weights, sperm concentrations and percentage of motile sperms, as well as the increase in abnormal sperm rate. LBP administration to DOX‐treated rats successfully reversed the changes in MDA and GHS‐Px levels. Compared with the control, pretreatment with LBP significantly increased the plasma testosterone level in the LBP + DOX group. The histopathology examinations further confirmed that LBP effectively attenuated DOX‐induced severe degenerative changes of seminiferous tubules. This study illustrated the capability of LBP in attenuating testicular oxidative stress and protecting testis‐specific toxicity in DOX‐exposed rats. |
| doi_str_mv | 10.1002/ptr.3633 |
| format | Article |
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Male Sprague‐Dawley rats were treated with distilled water (4 mL/kg) or LBP (200 mg/kg, p.o.) daily for 10 days and followed by saline (0.9 %, 10 mL/kg) or DOX (10 mg/kg) intravenous injection at day 7. Pretreatment with LBP ameliorated DOX‐induced reduction in the testicular weights, sperm concentrations and percentage of motile sperms, as well as the increase in abnormal sperm rate. LBP administration to DOX‐treated rats successfully reversed the changes in MDA and GHS‐Px levels. Compared with the control, pretreatment with LBP significantly increased the plasma testosterone level in the LBP + DOX group. The histopathology examinations further confirmed that LBP effectively attenuated DOX‐induced severe degenerative changes of seminiferous tubules. This study illustrated the capability of LBP in attenuating testicular oxidative stress and protecting testis‐specific toxicity in DOX‐exposed rats.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.3633</identifier><identifier>PMID: 22016089</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; Antibiotics, Antineoplastic - toxicity ; antioxidant ; Antioxidants - pharmacology ; Biological and medical sciences ; doxorubicin ; Doxorubicin - toxicity ; Drugs, Chinese Herbal - pharmacology ; General pharmacology ; Humans ; intravenous injection ; Lipid Peroxidation - drug effects ; Lycium - chemistry ; Lycium barbarum ; Lycium barbarum polysaccharides ; Male ; Malondialdehyde - metabolism ; Medical sciences ; Organ Size - drug effects ; Organ Specificity ; oxidative stress ; Oxidative Stress - drug effects ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; polysaccharides ; protective effect ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; seminiferous tubules ; Seminiferous Tubules - drug effects ; sperm concentration ; spermatozoa ; Spermatozoa - drug effects ; Spermatozoa - physiology ; testicular toxicity ; Testis - drug effects ; Testis - metabolism ; Testis - pathology ; testosterone ; Testosterone - blood ; toxicity</subject><ispartof>Phytotherapy research, 2012-05, Vol.26 (5), p.716-721</ispartof><rights>Copyright © 2011 John Wiley & Sons, Ltd.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4793-d97604ea72061ea7bdc9111646c4c8dc78b230f42f18f1e0290fa61f28a30763</citedby><cites>FETCH-LOGICAL-c4793-d97604ea72061ea7bdc9111646c4c8dc78b230f42f18f1e0290fa61f28a30763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.3633$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.3633$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25862232$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22016089$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xin, Yan‐Fei</creatorcontrib><creatorcontrib>You, Zhen‐Qiang</creatorcontrib><creatorcontrib>Gao, Hai‐yan</creatorcontrib><creatorcontrib>Zhou, Guo‐Liang</creatorcontrib><creatorcontrib>Chen, Yun‐Xiang</creatorcontrib><creatorcontrib>Yu, Jian</creatorcontrib><creatorcontrib>Xuan, Yao‐Xian</creatorcontrib><title>Protective Effect of Lycium barbarum Polysaccharides Against Doxorubicin‐induced Testicular Toxicity in Rats</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>The present study aimed to investigate whether Lycium barbarum polysaccharides (LBP) would protect against doxorubicin (DOX)‐induced testicular toxicity. Male Sprague‐Dawley rats were treated with distilled water (4 mL/kg) or LBP (200 mg/kg, p.o.) daily for 10 days and followed by saline (0.9 %, 10 mL/kg) or DOX (10 mg/kg) intravenous injection at day 7. Pretreatment with LBP ameliorated DOX‐induced reduction in the testicular weights, sperm concentrations and percentage of motile sperms, as well as the increase in abnormal sperm rate. LBP administration to DOX‐treated rats successfully reversed the changes in MDA and GHS‐Px levels. Compared with the control, pretreatment with LBP significantly increased the plasma testosterone level in the LBP + DOX group. The histopathology examinations further confirmed that LBP effectively attenuated DOX‐induced severe degenerative changes of seminiferous tubules. This study illustrated the capability of LBP in attenuating testicular oxidative stress and protecting testis‐specific toxicity in DOX‐exposed rats.</description><subject>Animals</subject><subject>Antibiotics, Antineoplastic - toxicity</subject><subject>antioxidant</subject><subject>Antioxidants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>doxorubicin</subject><subject>Doxorubicin - toxicity</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>intravenous injection</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lycium - chemistry</subject><subject>Lycium barbarum</subject><subject>Lycium barbarum polysaccharides</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Medical sciences</subject><subject>Organ Size - drug effects</subject><subject>Organ Specificity</subject><subject>oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>polysaccharides</subject><subject>protective effect</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>seminiferous tubules</subject><subject>Seminiferous Tubules - drug effects</subject><subject>sperm concentration</subject><subject>spermatozoa</subject><subject>Spermatozoa - drug effects</subject><subject>Spermatozoa - physiology</subject><subject>testicular toxicity</subject><subject>Testis - drug effects</subject><subject>Testis - metabolism</subject><subject>Testis - pathology</subject><subject>testosterone</subject><subject>Testosterone - blood</subject><subject>toxicity</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10cFq3DAQBmBRWpptUugTJLoUenEykmzJOoZtkgaWZklc2puQZSlR6rUXyW7XtzxCnrFPEoXdpqeCYAb0oRl-IfSBwDEBoCfrIRwzztgrNCMgZUYKwV6jGciCZDkpf-yhdzHeA4CkkL9Fe5QC4VDKGeqWoR-sGfwvi8-cSx3uHV5Mxo8rXOuQTmqWfTtFbcydDr6xEZ_eat_FAX_uN30Ya2989-fh0XfNaGyDKxsHb8ZWB1z1m3Q5TNh3-FoP8QC9cbqN9v2u7qPq_Kyaf8kWVxeX89NFZnIhWdZIwSG3WlDgJJW6MZIQwnNuclM2RpQ1ZeBy6kjpiAUqwWlOHC01A8HZPvq0fdaEPsZgnVoHv9JhUgTUc2IqJaaeE0v0cEvXY72yzQv8G1ECH3dAR6NbF3RnfPznipJTymhy2db99q2d_jtQLavr3eCd93Gwmxevw0_FBROF-v71QhViIee0KtR58kdb73Sv9G1IO3y7SUvm6VsJUCbYEx9DnC0</recordid><startdate>201205</startdate><enddate>201205</enddate><creator>Xin, Yan‐Fei</creator><creator>You, Zhen‐Qiang</creator><creator>Gao, Hai‐yan</creator><creator>Zhou, Guo‐Liang</creator><creator>Chen, Yun‐Xiang</creator><creator>Yu, Jian</creator><creator>Xuan, Yao‐Xian</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201205</creationdate><title>Protective Effect of Lycium barbarum Polysaccharides Against Doxorubicin‐induced Testicular Toxicity in Rats</title><author>Xin, Yan‐Fei ; You, Zhen‐Qiang ; Gao, Hai‐yan ; Zhou, Guo‐Liang ; Chen, Yun‐Xiang ; Yu, Jian ; Xuan, Yao‐Xian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4793-d97604ea72061ea7bdc9111646c4c8dc78b230f42f18f1e0290fa61f28a30763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Antibiotics, Antineoplastic - toxicity</topic><topic>antioxidant</topic><topic>Antioxidants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>doxorubicin</topic><topic>Doxorubicin - toxicity</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>intravenous injection</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lycium - chemistry</topic><topic>Lycium barbarum</topic><topic>Lycium barbarum polysaccharides</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Medical sciences</topic><topic>Organ Size - drug effects</topic><topic>Organ Specificity</topic><topic>oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>polysaccharides</topic><topic>protective effect</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>seminiferous tubules</topic><topic>Seminiferous Tubules - drug effects</topic><topic>sperm concentration</topic><topic>spermatozoa</topic><topic>Spermatozoa - drug effects</topic><topic>Spermatozoa - physiology</topic><topic>testicular toxicity</topic><topic>Testis - drug effects</topic><topic>Testis - metabolism</topic><topic>Testis - pathology</topic><topic>testosterone</topic><topic>Testosterone - blood</topic><topic>toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xin, Yan‐Fei</creatorcontrib><creatorcontrib>You, Zhen‐Qiang</creatorcontrib><creatorcontrib>Gao, Hai‐yan</creatorcontrib><creatorcontrib>Zhou, Guo‐Liang</creatorcontrib><creatorcontrib>Chen, Yun‐Xiang</creatorcontrib><creatorcontrib>Yu, Jian</creatorcontrib><creatorcontrib>Xuan, Yao‐Xian</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xin, Yan‐Fei</au><au>You, Zhen‐Qiang</au><au>Gao, Hai‐yan</au><au>Zhou, Guo‐Liang</au><au>Chen, Yun‐Xiang</au><au>Yu, Jian</au><au>Xuan, Yao‐Xian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective Effect of Lycium barbarum Polysaccharides Against Doxorubicin‐induced Testicular Toxicity in Rats</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2012-05</date><risdate>2012</risdate><volume>26</volume><issue>5</issue><spage>716</spage><epage>721</epage><pages>716-721</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>The present study aimed to investigate whether Lycium barbarum polysaccharides (LBP) would protect against doxorubicin (DOX)‐induced testicular toxicity. Male Sprague‐Dawley rats were treated with distilled water (4 mL/kg) or LBP (200 mg/kg, p.o.) daily for 10 days and followed by saline (0.9 %, 10 mL/kg) or DOX (10 mg/kg) intravenous injection at day 7. Pretreatment with LBP ameliorated DOX‐induced reduction in the testicular weights, sperm concentrations and percentage of motile sperms, as well as the increase in abnormal sperm rate. LBP administration to DOX‐treated rats successfully reversed the changes in MDA and GHS‐Px levels. Compared with the control, pretreatment with LBP significantly increased the plasma testosterone level in the LBP + DOX group. The histopathology examinations further confirmed that LBP effectively attenuated DOX‐induced severe degenerative changes of seminiferous tubules. This study illustrated the capability of LBP in attenuating testicular oxidative stress and protecting testis‐specific toxicity in DOX‐exposed rats.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>22016089</pmid><doi>10.1002/ptr.3633</doi><tpages>6</tpages></addata></record> |
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| ispartof | Phytotherapy research, 2012-05, Vol.26 (5), p.716-721 |
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| subjects | Animals Antibiotics, Antineoplastic - toxicity antioxidant Antioxidants - pharmacology Biological and medical sciences doxorubicin Doxorubicin - toxicity Drugs, Chinese Herbal - pharmacology General pharmacology Humans intravenous injection Lipid Peroxidation - drug effects Lycium - chemistry Lycium barbarum Lycium barbarum polysaccharides Male Malondialdehyde - metabolism Medical sciences Organ Size - drug effects Organ Specificity oxidative stress Oxidative Stress - drug effects Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments polysaccharides protective effect Random Allocation Rats Rats, Sprague-Dawley seminiferous tubules Seminiferous Tubules - drug effects sperm concentration spermatozoa Spermatozoa - drug effects Spermatozoa - physiology testicular toxicity Testis - drug effects Testis - metabolism Testis - pathology testosterone Testosterone - blood toxicity |
| title | Protective Effect of Lycium barbarum Polysaccharides Against Doxorubicin‐induced Testicular Toxicity in Rats |
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