Further antibacterial diterpenes from the bark and leaves of Juniperus procera hochst. ex Endl
The bark of Juniperus procera yielded three antibacterial diterpenoids, (+)‐E‐communic acid (1), (+)‐Z‐communic acid (2) and (+)‐totarol (3). Compound 2 exhibited significant activity against Gram‐positive bacteria, while 1 was found to be less active. Compound 3, on the other hand, demonstrated pot...
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| Veröffentlicht in: | Phytotherapy research 1995-12, Vol.9 (8), p.584-588 |
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| container_title | Phytotherapy research |
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| creator | Muhammad, Ilias Mossa, Jaber S. Al-Yahya, Mohammed A. Ramadan, Ahmed F. El-Feraly, Farouk S. |
| description | The bark of Juniperus procera yielded three antibacterial diterpenoids, (+)‐E‐communic acid (1), (+)‐Z‐communic acid (2) and (+)‐totarol (3). Compound 2 exhibited significant activity against Gram‐positive bacteria, while 1 was found to be less active. Compound 3, on the other hand, demonstrated potent activity against Mycobacterium organisms, while its corresponding 3β‐hydroxy‐derivative 4 was found to be inactive. The chromatographic separation of (+)‐Z‐communic acid (2) from (+)‐E‐communic acid (1) and those previously unreported spectral data of 1 and 2 are described. In addition, the leaves yielded (+)‐8α‐acetoxyelemol, β‐peltatin A methyl ether and deoxypodophyllotoxin. |
| doi_str_mv | 10.1002/ptr.2650090810 |
| format | Article |
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Compound 2 exhibited significant activity against Gram‐positive bacteria, while 1 was found to be less active. Compound 3, on the other hand, demonstrated potent activity against Mycobacterium organisms, while its corresponding 3β‐hydroxy‐derivative 4 was found to be inactive. The chromatographic separation of (+)‐Z‐communic acid (2) from (+)‐E‐communic acid (1) and those previously unreported spectral data of 1 and 2 are described. In addition, the leaves yielded (+)‐8α‐acetoxyelemol, β‐peltatin A methyl ether and deoxypodophyllotoxin.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.2650090810</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>antibacterial ; bioautography ; Biological and medical sciences ; Cupressaceae ; diterpenes ; E-communic acid ; General pharmacology ; J. excelsa ; Juniperus procera ; Medical sciences ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; totarol ; Z-communic acid</subject><ispartof>Phytotherapy research, 1995-12, Vol.9 (8), p.584-588</ispartof><rights>Copyright © 1995 John Wiley & Sons, Ltd.</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3540-d8092faddefaff2133cf80972d1aa172e29b4e5b21cfb21a5b99f4e87b09db3a3</citedby><cites>FETCH-LOGICAL-c3540-d8092faddefaff2133cf80972d1aa172e29b4e5b21cfb21a5b99f4e87b09db3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.2650090810$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.2650090810$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2945349$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Muhammad, Ilias</creatorcontrib><creatorcontrib>Mossa, Jaber S.</creatorcontrib><creatorcontrib>Al-Yahya, Mohammed A.</creatorcontrib><creatorcontrib>Ramadan, Ahmed F.</creatorcontrib><creatorcontrib>El-Feraly, Farouk S.</creatorcontrib><title>Further antibacterial diterpenes from the bark and leaves of Juniperus procera hochst. ex Endl</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>The bark of Juniperus procera yielded three antibacterial diterpenoids, (+)‐E‐communic acid (1), (+)‐Z‐communic acid (2) and (+)‐totarol (3). Compound 2 exhibited significant activity against Gram‐positive bacteria, while 1 was found to be less active. Compound 3, on the other hand, demonstrated potent activity against Mycobacterium organisms, while its corresponding 3β‐hydroxy‐derivative 4 was found to be inactive. The chromatographic separation of (+)‐Z‐communic acid (2) from (+)‐E‐communic acid (1) and those previously unreported spectral data of 1 and 2 are described. In addition, the leaves yielded (+)‐8α‐acetoxyelemol, β‐peltatin A methyl ether and deoxypodophyllotoxin.</description><subject>antibacterial</subject><subject>bioautography</subject><subject>Biological and medical sciences</subject><subject>Cupressaceae</subject><subject>diterpenes</subject><subject>E-communic acid</subject><subject>General pharmacology</subject><subject>J. excelsa</subject><subject>Juniperus procera</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>totarol</subject><subject>Z-communic acid</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNqFkD1PwzAQhi0EEqWwMntgTfFXmniEqrSgqiBUoBPWxbHVQJpEdgrtv8coqIiJxbbOz3N3ehE6p2RACWGXTesGbBgTIklKyQHqUSJlROOEH6IekTGNBE2Xx-jE-zcSKEZED73ebFy7Mg5D1RYZ6Na4AkqcF-HRmMp4bF29xgHBGbj3gOW4NPARPmqL7zZV0Ri38bhxtTYO8KrWK98OsNnicZWXp-jIQunN2c_dR08348VoGs3uJ7ejq1mkeSxIlKdhHQt5bixYyyjn2oZSwnIKQBNmmMyEiTNGtQ0HxJmUVpg0yYjMMw68jwZdX-1q752xqnHFGtxOUaK-01EhHfWbThAuOqEBr6G0Dipd-L3FpIi5kAGTHfZZlGb3T1P1sHj8MyLq3MK3Zrt3Q4pqmPAkVi_ziUqv52K6XHD1zL8ALSGG1A</recordid><startdate>199512</startdate><enddate>199512</enddate><creator>Muhammad, Ilias</creator><creator>Mossa, Jaber S.</creator><creator>Al-Yahya, Mohammed A.</creator><creator>Ramadan, Ahmed F.</creator><creator>El-Feraly, Farouk S.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199512</creationdate><title>Further antibacterial diterpenes from the bark and leaves of Juniperus procera hochst. ex Endl</title><author>Muhammad, Ilias ; Mossa, Jaber S. ; Al-Yahya, Mohammed A. ; Ramadan, Ahmed F. ; El-Feraly, Farouk S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3540-d8092faddefaff2133cf80972d1aa172e29b4e5b21cfb21a5b99f4e87b09db3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>antibacterial</topic><topic>bioautography</topic><topic>Biological and medical sciences</topic><topic>Cupressaceae</topic><topic>diterpenes</topic><topic>E-communic acid</topic><topic>General pharmacology</topic><topic>J. excelsa</topic><topic>Juniperus procera</topic><topic>Medical sciences</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>totarol</topic><topic>Z-communic acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muhammad, Ilias</creatorcontrib><creatorcontrib>Mossa, Jaber S.</creatorcontrib><creatorcontrib>Al-Yahya, Mohammed A.</creatorcontrib><creatorcontrib>Ramadan, Ahmed F.</creatorcontrib><creatorcontrib>El-Feraly, Farouk S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muhammad, Ilias</au><au>Mossa, Jaber S.</au><au>Al-Yahya, Mohammed A.</au><au>Ramadan, Ahmed F.</au><au>El-Feraly, Farouk S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Further antibacterial diterpenes from the bark and leaves of Juniperus procera hochst. ex Endl</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>1995-12</date><risdate>1995</risdate><volume>9</volume><issue>8</issue><spage>584</spage><epage>588</epage><pages>584-588</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>The bark of Juniperus procera yielded three antibacterial diterpenoids, (+)‐E‐communic acid (1), (+)‐Z‐communic acid (2) and (+)‐totarol (3). Compound 2 exhibited significant activity against Gram‐positive bacteria, while 1 was found to be less active. Compound 3, on the other hand, demonstrated potent activity against Mycobacterium organisms, while its corresponding 3β‐hydroxy‐derivative 4 was found to be inactive. The chromatographic separation of (+)‐Z‐communic acid (2) from (+)‐E‐communic acid (1) and those previously unreported spectral data of 1 and 2 are described. In addition, the leaves yielded (+)‐8α‐acetoxyelemol, β‐peltatin A methyl ether and deoxypodophyllotoxin.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/ptr.2650090810</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0951-418X |
| ispartof | Phytotherapy research, 1995-12, Vol.9 (8), p.584-588 |
| issn | 0951-418X 1099-1573 |
| language | eng |
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| source | Access via Wiley Online Library |
| subjects | antibacterial bioautography Biological and medical sciences Cupressaceae diterpenes E-communic acid General pharmacology J. excelsa Juniperus procera Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments totarol Z-communic acid |
| title | Further antibacterial diterpenes from the bark and leaves of Juniperus procera hochst. ex Endl |
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