Antidiabetic effect of Olea europaea L. in normal and diabetic rats
The antidiabetic effect of an alcohol extract of olive (Olea europaea L.) leaves was investigated in normal and streptozotocin-induced diabetic rats. The oral administration of the olive leaves extract (0.1, 0.25 and 0.5 g/kg body wt) for 14 days significantly decreased the serum glucose, total chol...
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| Veröffentlicht in: | Phytotherapy research 2009-03, Vol.23 (3), p.347-350 |
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| creator | Eidi, A Eidi, M Darzi, R |
| description | The antidiabetic effect of an alcohol extract of olive (Olea europaea L.) leaves was investigated in normal and streptozotocin-induced diabetic rats. The oral administration of the olive leaves extract (0.1, 0.25 and 0.5 g/kg body wt) for 14 days significantly decreased the serum glucose, total cholesterol, triglycerides, urea, uric acid, creatinine, aspartate amino transferase (AST) and alanine amino transferase (ALT) while it increased the serum insulin in diabetic rats but not in normal rats (p < 0.05). A comparison was made between the action of olive leaves extract and glibenclamide (600 μg/kg), a known antidiabetic drug. The antidiabetic effect of the extract was more effective than that observed with glibenclamide. Copyright © 2008 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.2629 |
| format | Article |
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The oral administration of the olive leaves extract (0.1, 0.25 and 0.5 g/kg body wt) for 14 days significantly decreased the serum glucose, total cholesterol, triglycerides, urea, uric acid, creatinine, aspartate amino transferase (AST) and alanine amino transferase (ALT) while it increased the serum insulin in diabetic rats but not in normal rats (p < 0.05). A comparison was made between the action of olive leaves extract and glibenclamide (600 μg/kg), a known antidiabetic drug. The antidiabetic effect of the extract was more effective than that observed with glibenclamide. Copyright © 2008 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.2629</identifier><identifier>PMID: 18844257</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Administration, Oral ; Animals ; Biological and medical sciences ; diabetes ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - chemically induced ; Diabetes Mellitus, Experimental - drug therapy ; General pharmacology ; Glyburide - pharmacology ; hypoglycemic ; Hypoglycemic Agents - pharmacology ; Insulin - blood ; Male ; Medical sciences ; Olea - chemistry ; Olea europaea L ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. 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Res</addtitle><description>The antidiabetic effect of an alcohol extract of olive (Olea europaea L.) leaves was investigated in normal and streptozotocin-induced diabetic rats. The oral administration of the olive leaves extract (0.1, 0.25 and 0.5 g/kg body wt) for 14 days significantly decreased the serum glucose, total cholesterol, triglycerides, urea, uric acid, creatinine, aspartate amino transferase (AST) and alanine amino transferase (ALT) while it increased the serum insulin in diabetic rats but not in normal rats (p < 0.05). A comparison was made between the action of olive leaves extract and glibenclamide (600 μg/kg), a known antidiabetic drug. The antidiabetic effect of the extract was more effective than that observed with glibenclamide. Copyright © 2008 John Wiley & Sons, Ltd.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>diabetes</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Diabetes Mellitus, Experimental - chemically induced</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>General pharmacology</subject><subject>Glyburide - pharmacology</subject><subject>hypoglycemic</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Insulin - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Olea - chemistry</subject><subject>Olea europaea L</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves - chemistry</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1P3DAQBmALUcFCkfgFNJdKXLKdsZ3EOaJVWdquSvlSUS_WrD-qQDZZ2UGFf1-jjZYTJ_vw2PPOy9gxwhQB-Jf1EKa85PUOmyDUdY5FJXbZBOoCc4nqfp8dxPgAADUHucf2USkpeVFN2OysGxrb0NINjcmc984MWe-zy9ZR5p5Cv6Z0WUyzpsu6Pqyozaiz2fZFoCF-ZB88tdEdjechuzv_eju7yBeX82-zs0VuJGKdW15QKbivoCKu3FKqglD5opSldd6UHJQiVwrlpVmSRIuKyNbG2jqlspU4ZKebf03oYwzO63VoVhReNIJ-7UGnHvRrD4mebOj6ably9g2OiyfweQQUDbU-UGeauHUcsVIpdHL5xv1rWvfy7kD96_Z6HDz6Jg7ueespPOqyElWhf_-c6z9X3-H6x43Q98l_2nhPvaa_IWW4u-GAArAEwRHEf9L-i9w</recordid><startdate>200903</startdate><enddate>200903</enddate><creator>Eidi, A</creator><creator>Eidi, M</creator><creator>Darzi, R</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200903</creationdate><title>Antidiabetic effect of Olea europaea L. in normal and diabetic rats</title><author>Eidi, A ; Eidi, M ; Darzi, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4119-d25a632f707a28eb485a18f5646defc62088ae638f4cba41d18aad9cdd9fecd73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>diabetes</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Diabetes Mellitus, Experimental - chemically induced</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>General pharmacology</topic><topic>Glyburide - pharmacology</topic><topic>hypoglycemic</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Insulin - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Olea - chemistry</topic><topic>Olea europaea L</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves - chemistry</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eidi, A</creatorcontrib><creatorcontrib>Eidi, M</creatorcontrib><creatorcontrib>Darzi, R</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eidi, A</au><au>Eidi, M</au><au>Darzi, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antidiabetic effect of Olea europaea L. in normal and diabetic rats</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. 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Copyright © 2008 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>18844257</pmid><doi>10.1002/ptr.2629</doi><tpages>4</tpages></addata></record> |
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| ispartof | Phytotherapy research, 2009-03, Vol.23 (3), p.347-350 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Administration, Oral Animals Biological and medical sciences diabetes Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy General pharmacology Glyburide - pharmacology hypoglycemic Hypoglycemic Agents - pharmacology Insulin - blood Male Medical sciences Olea - chemistry Olea europaea L Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - pharmacology Plant Leaves - chemistry rat Rats Rats, Wistar |
| title | Antidiabetic effect of Olea europaea L. in normal and diabetic rats |
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