Synergistic antitumor effects of liposomal honokiol combined with adriamycin in breast cancer models
Honokiol, a novel antitumor agent, could induce apoptosis and inhibit the growth of vascular endothelium in several tumor cell lines and xenograft models. It has been suggested that the antitumor effect of chemotherapy could be increased by combining it with an antiangiogenesis agent in anticancer s...
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| Veröffentlicht in: | Phytotherapy research 2008-08, Vol.22 (8), p.1125-1132 |
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| creator | Hou, Wenli Chen, Lijuan Yang, Guangli Zhou, Hang Jiang, Qiqi Zhong, Zhenhua Hu, Jia Chen, Xiang Wang, Xianhuo Yuan, Yuan Tang, Minghai Wen, Jing Wei, Yuquan |
| description | Honokiol, a novel antitumor agent, could induce apoptosis and inhibit the growth of vascular endothelium in several tumor cell lines and xenograft models. It has been suggested that the antitumor effect of chemotherapy could be increased by combining it with an antiangiogenesis agent in anticancer strategy. The present study explored the potential to increase the antitumor effect of adriamycin by combining it with honokiol in mouse 4T1 breast cancer models, and the underlining mechanism was investigated. Honokiol was encapsulated in liposomes to improve the water insolubility. In vitro, liposomal honokiol inhibited the proliferation of 4T1 cells via apoptosis and significantly enhanced the apoptosis of 4T1 cells induced by adriamycin. In vivo, the systemic administration of liposomal honokiol and adriamycin significantly decreased tumor growth through increased tumor cell apoptosis compared with either treatment alone. Collectively, these findings suggest that liposomal honokiol may augment the induction of apoptosis in 4T1 cells in vitro and in vivo, and this combined treatment has shown synergistic suppression in tumor progression according to the analysis of isobologram. The present study may be important in future exploration of the potential application of the combined approach in the treatment of breast cancer. Copyright © 2008 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.2472 |
| format | Article |
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It has been suggested that the antitumor effect of chemotherapy could be increased by combining it with an antiangiogenesis agent in anticancer strategy. The present study explored the potential to increase the antitumor effect of adriamycin by combining it with honokiol in mouse 4T1 breast cancer models, and the underlining mechanism was investigated. Honokiol was encapsulated in liposomes to improve the water insolubility. In vitro, liposomal honokiol inhibited the proliferation of 4T1 cells via apoptosis and significantly enhanced the apoptosis of 4T1 cells induced by adriamycin. In vivo, the systemic administration of liposomal honokiol and adriamycin significantly decreased tumor growth through increased tumor cell apoptosis compared with either treatment alone. Collectively, these findings suggest that liposomal honokiol may augment the induction of apoptosis in 4T1 cells in vitro and in vivo, and this combined treatment has shown synergistic suppression in tumor progression according to the analysis of isobologram. The present study may be important in future exploration of the potential application of the combined approach in the treatment of breast cancer. Copyright © 2008 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.2472</identifier><identifier>PMID: 18570244</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>adriamycin ; Animals ; Antineoplastic Agents, Phytogenic - administration & dosage ; Antineoplastic Agents, Phytogenic - pharmacology ; Apoptosis - drug effects ; Biological and medical sciences ; Biphenyl Compounds - administration & dosage ; Biphenyl Compounds - pharmacology ; breast cancer ; Breast Neoplasms - blood supply ; Breast Neoplasms - drug therapy ; Breast Neoplasms - pathology ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; combined therapy ; Dose-Response Relationship, Drug ; Doxorubicin - administration & dosage ; Doxorubicin - pharmacology ; Drug Combinations ; Drug Screening Assays, Antitumor ; Drug Synergism ; Drugs, Chinese Herbal - administration & dosage ; Drugs, Chinese Herbal - pharmacology ; Female ; General pharmacology ; Lignans - administration & dosage ; Lignans - pharmacology ; liposomal honokiol ; Liposomes ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Neovascularization, Pathologic - drug therapy ; Neovascularization, Pathologic - metabolism ; Neovascularization, Pathologic - pathology ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; synergistic ; Xenograft Model Antitumor Assays</subject><ispartof>Phytotherapy research, 2008-08, Vol.22 (8), p.1125-1132</ispartof><rights>Copyright © 2008 John Wiley & Sons, Ltd.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4112-ab887940cc1b85f4cbe4b3a2e7f5aa41ac13002bea5cccbe77e8bbd23fe56c783</citedby><cites>FETCH-LOGICAL-c4112-ab887940cc1b85f4cbe4b3a2e7f5aa41ac13002bea5cccbe77e8bbd23fe56c783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.2472$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.2472$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20557568$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18570244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hou, Wenli</creatorcontrib><creatorcontrib>Chen, Lijuan</creatorcontrib><creatorcontrib>Yang, Guangli</creatorcontrib><creatorcontrib>Zhou, Hang</creatorcontrib><creatorcontrib>Jiang, Qiqi</creatorcontrib><creatorcontrib>Zhong, Zhenhua</creatorcontrib><creatorcontrib>Hu, Jia</creatorcontrib><creatorcontrib>Chen, Xiang</creatorcontrib><creatorcontrib>Wang, Xianhuo</creatorcontrib><creatorcontrib>Yuan, Yuan</creatorcontrib><creatorcontrib>Tang, Minghai</creatorcontrib><creatorcontrib>Wen, Jing</creatorcontrib><creatorcontrib>Wei, Yuquan</creatorcontrib><title>Synergistic antitumor effects of liposomal honokiol combined with adriamycin in breast cancer models</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>Honokiol, a novel antitumor agent, could induce apoptosis and inhibit the growth of vascular endothelium in several tumor cell lines and xenograft models. It has been suggested that the antitumor effect of chemotherapy could be increased by combining it with an antiangiogenesis agent in anticancer strategy. The present study explored the potential to increase the antitumor effect of adriamycin by combining it with honokiol in mouse 4T1 breast cancer models, and the underlining mechanism was investigated. Honokiol was encapsulated in liposomes to improve the water insolubility. In vitro, liposomal honokiol inhibited the proliferation of 4T1 cells via apoptosis and significantly enhanced the apoptosis of 4T1 cells induced by adriamycin. In vivo, the systemic administration of liposomal honokiol and adriamycin significantly decreased tumor growth through increased tumor cell apoptosis compared with either treatment alone. Collectively, these findings suggest that liposomal honokiol may augment the induction of apoptosis in 4T1 cells in vitro and in vivo, and this combined treatment has shown synergistic suppression in tumor progression according to the analysis of isobologram. The present study may be important in future exploration of the potential application of the combined approach in the treatment of breast cancer. Copyright © 2008 John Wiley & Sons, Ltd.</description><subject>adriamycin</subject><subject>Animals</subject><subject>Antineoplastic Agents, Phytogenic - administration & dosage</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Apoptosis - drug effects</subject><subject>Biological and medical sciences</subject><subject>Biphenyl Compounds - administration & dosage</subject><subject>Biphenyl Compounds - pharmacology</subject><subject>breast cancer</subject><subject>Breast Neoplasms - blood supply</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - pathology</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>combined therapy</subject><subject>Dose-Response Relationship, Drug</subject><subject>Doxorubicin - administration & dosage</subject><subject>Doxorubicin - pharmacology</subject><subject>Drug Combinations</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Drug Synergism</subject><subject>Drugs, Chinese Herbal - administration & dosage</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Female</subject><subject>General pharmacology</subject><subject>Lignans - administration & dosage</subject><subject>Lignans - pharmacology</subject><subject>liposomal honokiol</subject><subject>Liposomes</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Neovascularization, Pathologic - drug therapy</subject><subject>Neovascularization, Pathologic - metabolism</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>synergistic</subject><subject>Xenograft Model Antitumor Assays</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1LHTEUBuAglXq1hf6CNpuCm9F83swsi_ULRa0fWLoJJ5lEU2cml2RE7783lzvYVSGQRR7Om_Mi9IWSPUoI21-MaY8JxTbQjJKmqahU_AOakUbSStD69xbazvkvIaRhRHxEW7SWijAhZqi9WQ4uPYQ8BothGMP43MeEnffOjhlHj7uwiDn20OHHOMSnEDtsY2_C4Fr8EsZHDG0K0C9tGHA5JjnII7YwWJdwH1vX5U9o00OX3efp3kF3R4e3ByfV-eXx6cGP88oKSlkFpq5VI4i11NTSC2ucMByYU14CCAqW8rKtcSCtLY9KudqYlnHv5Nyqmu-g3fVcm2LOyXm9SKGHtNSU6FVRuhSlV0UV-nVNF8-md-0_ODVTwPcJQLbQ-VQWCvndMSKlkvNVZrV2L6Fzy_8G6qvb6yl48qVy9_ruIT3pueJK6vuLY_3z5OxM8F9_9HXx39beQ9TwkMof7m4YWTXRMM6E5G_orZpz</recordid><startdate>200808</startdate><enddate>200808</enddate><creator>Hou, Wenli</creator><creator>Chen, Lijuan</creator><creator>Yang, Guangli</creator><creator>Zhou, Hang</creator><creator>Jiang, Qiqi</creator><creator>Zhong, Zhenhua</creator><creator>Hu, Jia</creator><creator>Chen, Xiang</creator><creator>Wang, Xianhuo</creator><creator>Yuan, Yuan</creator><creator>Tang, Minghai</creator><creator>Wen, Jing</creator><creator>Wei, Yuquan</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200808</creationdate><title>Synergistic antitumor effects of liposomal honokiol combined with adriamycin in breast cancer models</title><author>Hou, Wenli ; Chen, Lijuan ; Yang, Guangli ; Zhou, Hang ; Jiang, Qiqi ; Zhong, Zhenhua ; Hu, Jia ; Chen, Xiang ; Wang, Xianhuo ; Yuan, Yuan ; Tang, Minghai ; Wen, Jing ; Wei, Yuquan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4112-ab887940cc1b85f4cbe4b3a2e7f5aa41ac13002bea5cccbe77e8bbd23fe56c783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>adriamycin</topic><topic>Animals</topic><topic>Antineoplastic Agents, Phytogenic - administration & dosage</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Apoptosis - drug effects</topic><topic>Biological and medical sciences</topic><topic>Biphenyl Compounds - administration & dosage</topic><topic>Biphenyl Compounds - pharmacology</topic><topic>breast cancer</topic><topic>Breast Neoplasms - blood supply</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - pathology</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>combined therapy</topic><topic>Dose-Response Relationship, Drug</topic><topic>Doxorubicin - administration & dosage</topic><topic>Doxorubicin - pharmacology</topic><topic>Drug Combinations</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Drug Synergism</topic><topic>Drugs, Chinese Herbal - administration & dosage</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Female</topic><topic>General pharmacology</topic><topic>Lignans - administration & dosage</topic><topic>Lignans - pharmacology</topic><topic>liposomal honokiol</topic><topic>Liposomes</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Neovascularization, Pathologic - drug therapy</topic><topic>Neovascularization, Pathologic - metabolism</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. 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Res</addtitle><date>2008-08</date><risdate>2008</risdate><volume>22</volume><issue>8</issue><spage>1125</spage><epage>1132</epage><pages>1125-1132</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>Honokiol, a novel antitumor agent, could induce apoptosis and inhibit the growth of vascular endothelium in several tumor cell lines and xenograft models. It has been suggested that the antitumor effect of chemotherapy could be increased by combining it with an antiangiogenesis agent in anticancer strategy. The present study explored the potential to increase the antitumor effect of adriamycin by combining it with honokiol in mouse 4T1 breast cancer models, and the underlining mechanism was investigated. Honokiol was encapsulated in liposomes to improve the water insolubility. In vitro, liposomal honokiol inhibited the proliferation of 4T1 cells via apoptosis and significantly enhanced the apoptosis of 4T1 cells induced by adriamycin. In vivo, the systemic administration of liposomal honokiol and adriamycin significantly decreased tumor growth through increased tumor cell apoptosis compared with either treatment alone. Collectively, these findings suggest that liposomal honokiol may augment the induction of apoptosis in 4T1 cells in vitro and in vivo, and this combined treatment has shown synergistic suppression in tumor progression according to the analysis of isobologram. The present study may be important in future exploration of the potential application of the combined approach in the treatment of breast cancer. Copyright © 2008 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>18570244</pmid><doi>10.1002/ptr.2472</doi><tpages>8</tpages></addata></record> |
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| ispartof | Phytotherapy research, 2008-08, Vol.22 (8), p.1125-1132 |
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| subjects | adriamycin Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Biological and medical sciences Biphenyl Compounds - administration & dosage Biphenyl Compounds - pharmacology breast cancer Breast Neoplasms - blood supply Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects combined therapy Dose-Response Relationship, Drug Doxorubicin - administration & dosage Doxorubicin - pharmacology Drug Combinations Drug Screening Assays, Antitumor Drug Synergism Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - pharmacology Female General pharmacology Lignans - administration & dosage Lignans - pharmacology liposomal honokiol Liposomes Medical sciences Mice Mice, Inbred BALB C Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments synergistic Xenograft Model Antitumor Assays |
| title | Synergistic antitumor effects of liposomal honokiol combined with adriamycin in breast cancer models |
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