Toki-to protects dopaminergic neurons in the substantia nigra from neurotoxicity of MPTP in mice

Parkinson's disease (PD) is a neurodegenerative disease of the brain characterized by the progressive loss of dopaminergic neurons in the substantia nigra (SN). No clinically proven drugs that may halt or retard the progression of PD have been reported. This study examined the anti-PD effect of...

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Veröffentlicht in:	Phytotherapy research 2007-09, Vol.21 (9), p.868-873
Hauptverfasser:	Sakai, Risa, Irie, Yoshifumi, Murata, Takeshi, Ishige, Atsushi, Anjiki, Naoko, Watanabe, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Behavior, Animal Biological and medical sciences Dopamine - metabolism Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Gene Expression Regulation - drug effects General pharmacology Japan Male Medical sciences Medicine, Traditional Mice Mice, Inbred C57BL MPTP Neurons - metabolism Neuroprotective Agents - administration & dosage Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Parkinson's disease Parkinsonian Disorders - chemically induced Parkinsonian Disorders - drug therapy Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plants, Medicinal pole test Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis serum and glucocorticoid-regulated kinase (SGK) Substantia Nigra - metabolism Toki-to
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