Inhibition of protein tyrosine phosphatase 1B by lignans from Myristica fragrans

Inhibition of protein tyrosine phosphatase 1B (PTP1B) has been proposed as one of the drug targets for treating type 2 diabetes and obesity. Bioassay‐guided fractionation of a MeOH extract of the semen of Myristica fragrans Houtt. (Myristicaceae) afforded PTP1B inhibitory compounds, meso‐dihydroguai...

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Veröffentlicht in:	Phytotherapy research 2006-08, Vol.20 (8), p.680-682
Hauptverfasser:	Yang, Senugmi, Min Kyun, Na, Jang, Jun Pil, Kim, Kyung Ah, Kim, Bo Yeon, Sung, Nak Ju, Oh, Won Keun, Ahn, Jong Seog
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line Chemical Fractionation Enzyme Inhibitors - pharmacology General pharmacology Granulocytes - drug effects Granulocytes - metabolism Guaiacol - analogs & derivatives Guaiacol - analysis Guaiacol - pharmacology Inhibitory Concentration 50 Lignans - analysis Lignans - pharmacology Medical sciences meso-dihydroguaiaretic acid Mice Myristica fragrans Myristica fragrans - chemistry otobaphenol Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phosphorylation - drug effects Plant Extracts - chemistry Plant Extracts - pharmacology Pollen - chemistry Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein Tyrosine Phosphatases - antagonists & inhibitors PTP1B Receptor, Insulin - drug effects Receptor, Insulin - metabolism type 2 diabetes
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