Cytotoxicity and antimicrobial activity of goniothalamin isolated from Bryonopsis laciniosa

The cytotoxicity and antimicrobial activity of goniothalamin isolated from Bryonopsis laciniosa was investigated. Goniothalamin showed potent cytotoxicity with LC50 values (5.03 µg/mL) comparable with the reference standard agent, gallic acid. It also showed weak antibacterial and signiﬁcant antifun...

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Veröffentlicht in:	Phytotherapy research 2003-12, Vol.17 (10), p.1155-1157
Hauptverfasser:	Mosaddik, M. Ashik, Haque, M. Ekramul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents - administration & dosage Anti-Infective Agents - pharmacology Anti-Infective Agents - therapeutic use antimicrobial activity Artemia - drug effects Bacillus cereus - drug effects Biological and medical sciences Bryonopsis laciniosa Cucurbitaceae cytotoxicity Dose-Response Relationship, Drug General pharmacology goniothalamin Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Lethal Dose 50 Medical sciences Microbial Sensitivity Tests Mitosporic Fungi - drug effects Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Pyrones - administration & dosage Pyrones - pharmacology Pyrones - therapeutic use Shigella - drug effects
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Zusammenfassung:	The cytotoxicity and antimicrobial activity of goniothalamin isolated from Bryonopsis laciniosa was investigated. Goniothalamin showed potent cytotoxicity with LC50 values (5.03 µg/mL) comparable with the reference standard agent, gallic acid. It also showed weak antibacterial and signiﬁcant antifungal activity against a wide range of gram positive and gram negative bacteria and fungi. The antibacterial (minimum inhibitory concentration) effect against Bacillus cereus and Shigella shiga was found to be 64 µg/mL. Copyright © 2003 John Wiley & Sons, Ltd.
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.1303